Results 101 to 110 of about 4,171 (266)

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Tek Dünya

Türkiye Ortadoğu Çalışmaları Dergisi
Aslen Amerikalı bir avukat olan Wendell Lewis Willkie (1892-1944), 5 Kasım 1940 tarihinde ABD’de yapılan başkanlık seçimlerinde Cumhuriyetçi Partinin adayı olarak Franklin D. Roosevelt’e karşı yürüttüğü başkanlık yarışını kaybedince Orta Doğu ülkeleri, Türkiye, Rusya, Yakut Cumhuriyeti ve Çin’e 49 günlük bir seyahat gerçekleştirir.
Enes Küçük, İsmail Düz
openaire   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

Advanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen, Michael B. Nguyen, Elliot Widd, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Houston Harding, Chloe Hurteau, Anika Yogi, Colin Luo, Rebecca L. Braden, Pedro Cabrales, Karen L. Christman   +14 more
wiley   +1 more source

Aspek Semantik dalam Teks-teks Agama Buddha

Jurnal Budi Pekerti Agama Buddha
This study examines the semantic dimensions in Buddhist religious texts, focusing on linguistic meaning, symbolism, and interpretation. Applying theoretical frameworks of semantics (lexical semantics, semiotics) and qualitative hermeneutical methodology, this research aims to understand how Buddhist teachings are constructed in texts and interpreted by
openaire   +1 more source

TEK KUŞAK TEK YOL PROJESİ VE TÜRKİYE’YE OLASI ETKİLERİ

Elektronik Sosyal Bilimler Dergisi, 2019
2013 yılı sonrası Çin Avrupa ile olan ticaret rotası üzerinde Tek Kuşak Tek Yol projesi başlatmıştır. Tarihi İpek Yolu sınırları üzerinde bulunan bu koridor Çin ve Avrupa’yı kara yolu, demiryolu ve limanlar vasıtası ile daha hızlı bir ulaşım ağı ile bağlamayı amaçlamaktadır. Bu aynı zamanda taşıma maliyetlerinde önemli bir düşüş sağlayacaktır. Projenin
openaire   +3 more sources

Lagomorph cranial biomechanics and the functional significance of the unique fenestrated rostrum of leporids

The Anatomical Record, EarlyView.
Abstract The crania of leporid lagomorphs are uniquely fenestrated, including the posterior cranial bones and the lateral portion of the maxilla. The functional significance of the highly fenestrated rostrum has received considerably little attention, despite being absent in other mammalian herbivores with a long rostrum.
Amber P. Wood‐Bailey, Alana C. Sharp
wiley   +1 more source

MODEL PENGEMBANGAN SOAL READING TOEFL BERBASIS TEKS-TEKS KEISLAMAN

Ta'dib, 2017
Problem of this research is the unfamiliarity of the topics in TOEFL test. Many of the topics are talking about American and Europe.  They are about American science, American history, American economic system, American culture and European culture.  The topics above are not familiar to the students of State Islamic College because they seldom study ...
openaire   +2 more sources