Results 51 to 60 of about 4,859,562 (258)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han   +16 more
wiley   +1 more source

The quest gone astray: tracing horror in alien invasion television series of the new millenium [PDF]

open access: yes, 2008
The starting years of the new millennium, explicitly the year 2005, witnessed an attempt to bring the science fiction genre to the mainstream like the attempt in the 1950s, however, this time not through the medium of film but through television ...
Ay, Tuba
core   +2 more sources

The sickest television show ever: paedogeddon and the British Press [PDF]

open access: yes, 2009
This paper explores the controversy caused by Paedogeddon, a one-off special of the Channel 4 series Brass Eye broadcast on July 26, 2001. Although the program sought to satirize inconsistencies in the way the British media treats and sensationalizes ...
Lockyer, S   +3 more
core   +1 more source

Gap‐Free Information Transfer in 4D‐STEM via Fusion of Complementary Scattering Channels

open access: yesAdvanced Science, EarlyView.
Fused Full‐Field STEM (FF‐STEM) is introduced as a 4D‐STEM imaging modality that combines direct ptychography with tilt‐corrected dark‐field reconstruction in a single acquisition. Fourier‐space fusion using Wiener‐type spectral weighting closes the low‐frequency contrast gap inherent to bright‐field methods, delivering gap‐free, dose‐efficient, near ...
Shengbo You   +15 more
wiley   +1 more source

Discussing Transnational Format Adaptation in Turkey: A Study on Kuzey Güney

open access: yesSeries. International journal of tv serial narratives, 2015
When celebrated Turkish TV series, Kuzey Güney (Ay Yapım, 2011 – 2013) started to be broadcast on a mainstream Turkish television channel Kanal D, a rumour appeared that it was adapted from the American television miniseries, Rich Man, Poor Man, aired in
Ayşegül Kesirli Unur
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

open access: yesAdvanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han   +11 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

open access: yesAdvanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma   +10 more
wiley   +1 more source

The Employment of the Subjective Camera in Television Series

open access: yesالاكاديمي
Television series have not been isolated from narrative and cinematic techniques but have benefited from them in developing their formal structure.
Nawfal Janan Bahnam
doaj   +1 more source

Les agentes artistiques et les enjeux du placement des comédien·ne·s

open access: yesBiens Symboliques, 2020
This article analyses what is at stake when talent agents place actors in television dramas and series, the production and consumption of which have gained increased cultural legitimacy in France over the past ten years.
Delphine Naudier
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

open access: yesAdvanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang   +14 more
wiley   +1 more source

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