Results 91 to 100 of about 18,522,447 (385)
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
Continuous time crystal coupled to a mechanical mode as a cavity-optomechanics-like platform
Nature CommunicationsTime crystals are an enigmatic phase of matter in which a quantum mechanical system displays repetitive, observable motion – they spontaneously break the time translation symmetry.
J. T. Mäkinen +4 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Progress in Earth and Planetary ScienceNitrogen isotope ratios of amino acids have been employed as a tool for illustrating the resource utilization of organisms and the trophic transfer between organisms in food webs.
Yuko Takizawa +6 more
doaj +1 more source
Charmonium at finite temperature [PDF]
, 2003 We study charmoinum correlators and spectral functions at finite temperature within the quenched approximation using isotropic lattices with lattice spacing a^-1=4.86 GeV and 9.72 GeV.
Asakawa +15 more
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
High Temperature Symmetry Nonrestoration [PDF]
, 1999 This is a short review on the subject of symmetry nonrestoration at high temperature. Special emphasis is put on experimental discoveries and different theoretical mechanisms.
Bajc, Borut
core +4 more sources
Single-molecule strong coupling at room temperature in plasmonic nanocavities
Nature, 2016 Photon emitters placed in an optical cavity experience an environment that changes how they are coupled to the surrounding light field. In the weak-coupling regime, the extraction of light from the emitter is enhanced.
R. Chikkaraddy +9 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
High temperature compositions Patent [PDF]
, 1967 Method for producing refractory molybdenum ...
Long, R. A.
core +1 more source