Results 71 to 80 of about 3,755,672 (209)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Control System For Fermilab's Low Temperature Upgrade
, 2007 Fermilab recently upgraded the Tevatron Cryogenic Systems to allow for lower temperature operation. This Lower Temperature Upgrade grew out of a desire to increase the Colliding Beam Physics energy from 900 GeV to 1000 GeV.
Norris Fermi National +1 more
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pH and Temperature Measurements in Biological Systems Utilizing the Environmental Sensitivity of Proton Transfer in Fluorophores [PDF]
, 2010 A great number of cellular processes can lead to local changes in proton concentration and temperature. So, it is desirable to be able to measure pH and temperature with non-invasive and spatially resolved methods.
Wong, Felix
core
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Project Report: Global Temperature and Salinity Profile Programme (GTSPP)
, 2009 The document summarizes the Global Temperature and Salinity Profile Programme (GTSPP) progress made covering the past two year period 2007-2008 and provides the GTSPP work plans in 2009 and 2010.
Sun, Charles
core
High temperature indentation of WC/Co hardmetals
, 2013 WC/Co is the material of choice for most high wear applications such as hot forming operations, drilling, cutting, machining and wire drawing due to its superior wear properties.
Zunega, Jonee Christine
core +1 more source