Results 111 to 120 of about 5,539,618 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Problems of the process of moistening raw cotton and cotton fiber. Cotton fiber wetting process problems

Системный анализ и прикладная информатика
The moistening of raw cotton and cotton fiber is a critical stage in the textile production process, significantly influencing the quality of the final product. However, achieving optimal moisture content presents numerous challenges.
Z. U. Ortiqov
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research on Energy-Saving Control of Automotive PEMFC Thermal Management System Based on Optimal Operating Temperature Tracking

Energies
To further enhance the economic performance of fuel cell vehicles (FCVs), this study develops a model-adaptive model predictive control (MPC) strategy.
Qi Jiang, Shusheng Xiong, Baoquan Sun, Ping Chen, Huipeng Chen, Shaopeng Zhu   +5 more
doaj   +1 more source

Concept for passive system to control gas flow independently of temperature [PDF]

, 1966
Volumetric flow rate of gas is maintained at a constant value independent of temperature by passing the gas through a parallel or series combination of turbulent flow and laminar flow restrictors.
Chavez, E. S., Milleman, S. E., Rickeman, E. C.   +2 more
core   +1 more source

Control of Stratification in Drying Particle Suspensions via Temperature Gradients

, 2019
A potential strategy for controlling stratification in a drying suspension of bidisperse particles is studied using molecular dynamics simulations. When the suspension is maintained at a constant temperature during fast drying, it can exhibit "small-on ...
Cheng, Shengfeng, Grest, Gary S., Tang, Yanfei   +2 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Internet of Things in Energy-Sensitive Processes: Application in a Refrigerated Warehouse

IEEE Access
This article aims to address an existing research gap in the study of the most widely used mathematical procedures in the field of automatic control of energy-sensitive industrial processes.
Julio Barreiro Montes, Sonia Zaragoza Fernandez, Vicente Diaz Casas   +2 more
doaj   +1 more source

Monitoring and Controlling Temperature [PDF]

Anaesthesia and Intensive Care, 1988
openaire   +3 more sources