Results 111 to 120 of about 3,130,753 (313)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Wide-temperature-range perfect superelasticity and giant elastocaloric effect in a high entropy alloy

, 2019
The high entropy alloy concept offers unique opportunities for the design of advanced materials with unprecedented properties. However, hitherto most of the research efforts are focused on structural materials.
Zhen Chen (129176), Xiaoming Sun (153120), Shaohui Li (329091), Daoyong Cong (2831018), Zhihua Nie (3167592), Yang Ren (747408), Yandong Wang (798914), Fuqiang Li (745173), Yong Zhang (5893), Runguang Li (6255449)   +9 more
core   +1 more source

Static Mechanical Properties of Aeolian Sand Improved with Silt Subjected to Varying Temperature and Pressure

Buildings
Delineating the mechanical characteristics of aeolian sand improved with silt under temperature action is of great significance for the construction and long-term operation of engineering materials in seasonal frozen areas.
Bojun Cui, Jian Xu, Xianxian Shao, Dechao Xu, Bingqi Zhang   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Water desalination using a temperature gradient

, 2019
A new concept for reverse osmosis is identified based on the use of a temperature gradient instead of pressure. When the temperature of the permeate-side of the membrane is higher than the feed-side then a significant driving force exists for water ...
Tokay, Begum, Robinson, John, Taqi, Ali, Meehan, Joseph, Binner, Eleanor   +4 more
core   +1 more source

Millennial temperature reconstruction intercomparison and evaluation [PDF]

, 2006
There has been considerable recent interest in paleoclimate reconstructions of the temperature history of the last millennium. A wide variety of techniques have been used.
J. Esper, Weber, SL, Juckes, MN, Allen, Myles, M. R. Allen, Juckes, M. N., M. N. Juckes, S. L. Weber, Briffa, KR, G. C. Hegerl, Esper, J., A. Moberg, Hegerl, GC, Weber, S. L., T. J. Osborn, Esper, J, Hegerl, G. C., Osborn, TJ, Allen, M. R., Moberg, A., Briffa, K. R., Osborn, T. J., Zorita, E., Moberg, A, K. R. Briffa, Allen, Myles R., Allen, MR   +26 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The intrinsic temperature effect of the Raman spectra of graphite

, 1999
The Raman spectra of ion-implanted highly oriented pyrolytic graphite (HOPG) are reported, in which an additional mode at 1083 cm(-1) and three doublet structures in the positions of similar to 1350, similar to 2450, and similar to 2710 cm(-1) are ...
Tan PH,Chinese Acad Sci,Inst Semicond,Natl Lab Superlattices & Microstruct,Beijing 100083,Peoples R China., Deng YM, Zhao Q, Tan PH, Cheng WC   +4 more
core  

Acclimatory response to environmental temperature in two species of marine crab: the stenothermal cancer pagurus and the eurythermal carcinus maenas [PDF]

, 1996
Temperature acclimation effects on leg muscle plasma membrane composition and biophysical state, neuromuscular function and whole organism thermal tolerance, and their dependence on the background seasonal acclimatization were investigated in the ...
Cuculescu, Mirela, Cuculescu, M
core