Results 41 to 50 of about 1,780,646 (296)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Pressure-gradient-induced Alfven eigenmodes: II. Kinetic excitation with ion temperature gradient

open access: yes, 2009
The kinetic excitation of ideal magnetohydrodynamic (MHD) discrete Alfven eigenmodes in the second MHD ballooning stable domain is studied in the presence of a thermal ion temperature gradient (ITG), using linear gyrokinetic particle-in-cell simulations ...
Bierwage, Andreas   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Horizontal Distribution of Temperature Effect in Rubberized Concrete Pavement: A Case Study

open access: yesBuildings, 2023
Temperature distribution and the deformation behavior under temperature are important parameters in the design and evaluation of concrete pavements. In this paper, in order to study the horizontal distribution of the temperature effect on rubberized ...
Gaowang Zhang   +3 more
doaj   +1 more source

Magnonic analog of the Edelstein effect in antiferromagnetic insulators [PDF]

open access: yes, 2020
We investigate the nonequilibrium spin polarization due to a temperature gradient in antiferromagnetic insulators, which is the magnonic analog of the inverse spin-galvanic effect of electrons. We derive a linear-response theory of a temperature-gradient-
Kovalev, Alexey   +3 more
core   +1 more source

Gyrokinetic studies of the effect of beta on drift-wave stability in NCSX [PDF]

open access: yes, 2012
The gyrokinetic turbulence code GS2 was used to investigate the effects of plasma beta on linear, collisionless ion temperature gradient (ITG) modes and trapped electron modes (TEM) in National Compact Stellarator Experiment (NCSX) geometry.
Baumgaertel, J. A.   +4 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Thermal Bowing of Reinforced Concrete Elements Exposed to Non-Uniform Heating

open access: yesArchives of Civil Engineering, 2018
The paper presents the test description and results of thermal bowing of RC beams exposed to non-uniform heating at high temperature. Bending of a non-uniformly heated element is caused by free thermal elongation of the material it is made of. The higher
Kowalski R.   +2 more
doaj   +1 more source

Mirror symmetry breaking with limited enantioselective autocatalysis and temperature gradients: a stability survey

open access: yes, 2012
We analyze limited enantioselective (LES) autocatalysis in a temperature gradient and with internal flow/recycling of hot and cold material. Microreversibility forbids broken mirror symmetry for LES in the presence of a temperature gradient alone.
Blanco, Celia   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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