Results 41 to 50 of about 849,151 (266)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Design, Construction and Performance Evaluation of an Indirect Solar Dryer for Fermented Cacao Beans [PDF]

Philippine E-Journal for Applied Research and Development, 2017
A solar dryer adopting the structural arrangement of a direct-type and the heating mode of an indirect-type was constructed and tested for drying fermented cacao beans.
Juanito D. Burguillos, Jessie C. Elauria, Irene De Vera   +2 more
doaj  

Assessment of AIRS Version 7 Temperature Profiles and Low-Level Inversions with GRUAN Radiosonde Observations in the Arctic

Remote Sensing, 2023
The extensive global climate observing system (GCOS) reference upper-air network (GRUAN) datasets provide a chance to validate newly released Atmospheric Infrared Sounder (AIRS) version 7 (v7) products over the Arctic.
Lei Zhang, Minghu Ding, Xiangdong Zheng, Junming Chen, Jianping Guo, Lingen Bian   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimisation of Thermal and Geometric Parameters of Cylindrical Fins during Natural Convection

Energies, 2023
The efficient use of energy is a crucial goal related to the world economy, and efforts are aimed at reducing energy demand for the same quality and quantity of products and services. The drive to improve energy efficiency in the context of technological
Florent Bunjaku, Risto V. Filkoski
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Inversion Method for Fiber-Optic Monitoring of Water Injection Profiles in Offshore Extended-Reach Wells

Cejing jishu
Distributed temperature sensing (DTS) technology finds increasing application in injection/production dynamics monitoring in offshore wells. However, diagnosing the injection profile of offshore extended-reach wells based on DTS data remains challenging.
RAN Feifei, LUO Hongwen, LI ying, LI Haitao, AI Wenbin, ZHANG Xiliang, XIONG Hanlan, CHEN Bingqi, PAN Xiaoyi   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Investigation of multi-stage desalination using a passive solar-driven membrane (PSDM) system: a critical analysis for unserved and underserved areas (UUA) in the Philippines

European Journal of Materials
The utilization of alternative and sustainable desalination methods geared towards geographically isolated and disadvantaged areas is gaining attention.
Rhys John D. Pacio, Karl June T. Paredes, Mark Cassius E. Pacheco, Glebert C. Dadol, Lorenz Inri C. Banabatac, Victoria F. Napisa, Noel Peter B. Tan   +6 more
doaj   +1 more source

Computer simulation for trimming exit temperature profile from low emission combustor [PDF]

Компьютерные исследования и моделирование, 2014
It is discussed peculiarities of forming gas temperature fields in gas turbine engine low emission combustors. It is shown the influence of burn-up rate on combustor outlet temperature and proposed recommendation for design the dilution system for the ...
K. S. Pugach
doaj   +1 more source