Results 71 to 80 of about 260,402 (260)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

‘Staying Hot’: Investigating the influence of overnight conditions on the penile skin temperature during male sexual arousal—A novel methodology for nocturnal erection detection

BJUI Compass
Objective The objective of this study is to assess the impact of overnight environmental conditions on erectile penile temperature within a controlled setting, with the aim of investigating the feasibility of using temperature measurements for nocturnal ...
Hille J. Torenvlied, Evelien Trip, Wouter Olthuis, Loes I. Segerink, Jack J. H. Beck   +4 more
doaj   +1 more source

Application of Distributed Optical Fiber Measurement Technology in Shale Gas Production Profile

Shiyou jixie, 2022
In shale gas horizontal wells,traditional gas production profile testing methods are prone to problems such as instrument failure,large testing error and limited monitoring duration due to complex downhole flow regime,many debris impurities in the ...
Wang Hui
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tunable luminescence and ratiometric temperature sensing by hierarchical self-assembly of lanthanide-organic cage

Nano Research
Luminescent materials with tunable emission wavelengths/colors hold great potential for smart response devices, data security, sensors, and so on. However, development of stimuli-responsive luminescent materials with traditional organic or inorganic ...
Xuan Deng, Ran Li, Li-Peng Zhou, Xiao-Fang Duan, Xiu-Yan Cheng, Shao-Jun Hu, Qing-Fu Sun   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Luminescence Intensity Ratio and Principal Component Analysis-Assisted Thermometry in Pr³⁺-Activated Inorganic Hosts

Inorganics
Temperature-dependent luminescence of Pr3+-doped materials was investigated using both conventional luminescence intensity ratio (LIR) and principal component analysis (PCA)-based thermometry.
Vesna Đorđević, Zoran Ristić, Anđela Rajčić, Ljubica Đačanin Far, Mina Medić, Željka Antić, Miroslav D. Dramićanin   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Composite-Structured Anti-Resonant Fiber with High Temperature Sensitivity for Cancer Cell Detection

Sensors
This study proposes a novel anti-resonant fiber sensing structure based on a composite “egg-shaped” configuration with surface plasmon resonance (SPR) effect.
Ruifan Wu, Qiming Wang, Yongqi Gai, Xiaolan Zhang, Xinru Shan, Danping Jia   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source