Results 131 to 140 of about 3,144,500 (368)
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Bio-ProtocolGene-edited human pluripotent stem cells provide attractive model systems to functionally interrogate the role of specific genetic variants in relevant cell types.
Berta de La Cruz +6 more
doaj +1 more source
Self-Modeling Based Diagnosis of Software-Defined Networks
, 2015 Networks built using SDN (Software-Defined Networks) and NFV (Network Functions Virtualization) approaches are expected to face several challenges such as scalability, robustness and resiliency.
Crespi, Noel +2 more
core +1 more source
Evolutionary Optimisation Methods for Template Based Image Registration [PDF]
arXiv, 2007 This paper investigates the use of evolutionary optimisation techniques to register a template with a scene image. An error function is created to measure the correspondence of the template to the image. The problem presented here is to optimise the horizontal, vertical and scaling parameters that register the template with the scene.
arxiv
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
F1000Research, 2023 A sound analysis of DNA sequencing data is important to extract meaningful information and infer quantities of interest. Sequencing and mapping errors coupled with low and variable coverage hamper the identification of genotypes and variants and the ...
Alex Mas-Sandoval +3 more
doaj
Cooperative Binding of Heat Shock Factor to the Yeast \u3ci\u3eHSP82\u3c/i\u3e Promoter In Vivo and In Vitro [PDF]
, 1999 revious work has shown that heat shock factor (HSF) plays a central role in remodeling the chromatin structure of the yeastHSP82 promoter via constitutive interactions with its high-affinity binding site, heat shock element 1 (HSE1).
Erkine, Alexander M. +3 more
core +1 more source
Detection Strategies for Extreme Mass Ratio Inspirals
, 2010 The capture of compact stellar remnants by galactic black holes provides a unique laboratory for exploring the near horizon geometry of the Kerr spacetime, or possible departures from general relativity if the central cores prove not to be black holes ...
Arnaud K A +20 more
core +1 more source
Prior Knowledge Helps Improve Beam Angle Optimization Efficiency in Radiotherapy Planning [PDF]
arXiv, 2018 One of the grand challenges in intensity-modulated radiotherapy (IMRT) planning is to optimize the beam angles in a reasonable computation time. To demonstrate the value of prior knowledge on improving the efficiency of beam angle optimization (BAO) in IMRT, this study proposes a modified genetic algorithm (GA) by incorporating prior knowledge into the
arxiv
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source