Results 71 to 80 of about 166,801 (267)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

The association between high jugular bulb and mastoid pneumatization in adults

Frontiers in Neurology
PurposeThe purpose of this study was to analyze the relationship between the degree of high jugular bulb (HJB) and mastoid pneumatization using high-resolution computed tomography (HRCT).MethodsBetween April 2019 and June 2022, HRCT of the temporal bone ...
Chenyu Chen, Chenyu Chen, Chenyu Chen, Chenyu Chen, Chenyu Chen, Simin Weng, Simin Weng, Zhifeng Chen, Zhifeng Chen, Yuqing Chen, Yuqing Chen, Guangnan Yao, Guangnan Yao, Xiying Huang, Xiying Huang, Xi Gu, Xi Gu, Xi Gu, Xi Gu, Xi Gu, Chang Lin, Chang Lin, Chang Lin, Chang Lin, Chang Lin   +24 more
doaj   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Mature Teratoma of the Petrous Bone with Extension into the Cerebellopontine Angle: Case Report

Journal of Neurological Surgery Reports, 2013
Purpose Intracranial teratomas in children involving lateral structures such as the petrous portion of the temporal bone are very uncommon. The authors report a case of a petrous teratoma with significant extension into the cerebellopontine angle with ...
Nickalus Khan, Paul Klimo Jr., Julie Harreld, Gregory T. Armstrong, L. Madison Michael II   +4 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Terapi Medikamentosa pada Paralisis Saraf Fasialis Akibat Fraktur Tulang Temporal

Jurnal Kesehatan Andalas, 2015
AbstrakPendahuluan: Paralisis saraf fasialis merupakan salah satu komplikasi fraktur tulang temporal. Fraktur tulang temporal dapat berupa fraktur longitudinal, transversal maupun campuran.
Jacky Munilson, Yan Edward, Dedy Rusdi
doaj  

Building like a Coral—Parallelized, Multiscale Biofabrication

Advanced Materials, EarlyView.
Corals build stiff, strong, and inherently circular skeletal materials under resource‐ and energy‐limited conditions—offering blueprints for transformative materials. We synthesize the current understanding of coral biomineralization and reframe coral growth as a multiscale, parallelized biofabrication process.
Asma Rehman, Marta Peña Fernández, Kristina K. Beck, Gavin L. Foster, Sebastian J. Hennige, Uwe Wolfram   +5 more
wiley   +1 more source