Results 111 to 120 of about 3,944,943 (340)

Neuropsychological deficits in temporal lobe epilepsy: A comprehensive review

Annals of Indian Academy of Neurology, 2014
Temporal lobe epilepsy (TLE) is the most prevalent form of complex partial seizures with temporal lobe origin of electrical abnormality. Studies have shown that recurrent seizures affect all aspects of cognitive functioning, including memory, language ...
Fengqing Zhao, Hai Kang, Libo You, P. Rastogi, D. Venkatesh, M. Chandra   +5 more
semanticscholar   +1 more source

Anatomy of the Temporal Lobe

Epilepsy Research and Treatment, 2012
Only primates have temporal lobes, which are largest in man, accommodating 17% of the cerebral cortex and including areas with auditory, olfactory, vestibular, visual and linguistic functions. The hippocampal formation, on the medial side of the lobe, includes the parahippocampal gyrus, subiculum, hippocampus, dentate gyrus, and associated white matter,
openaire   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

Nature Communications, 2013
Temporal lobe epilepsy is the most common type of epilepsy in adults, is often medically refractory, and due to broad actions and long-time scales, current systemic treatments have major negative side-effects.
E. Krook-Magnuson, Caren Armstrong, M. Oijala, I. Soltesz   +3 more
semanticscholar   +1 more source

Pathological regional blood flow in opiate-dependent patients during withdrawal: A HMPAO-SPECT study [PDF]

, 1998
The aims of the present study were to investigate regional cerebral blood flow (rCBF) in heroin-dependent patients during withdrawal and to assess the relation between these changes and duration of heroin consumption and withdrawal data.
Krappel, C., Broich, K., Klemm, E., Biersack, H. J., Hoflich, G., Danos, P., Kasper, S., Grunwald, F., Möller, Hans-Jürgen, Overbeck, B.   +9 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

New Approaches to Studying Silent Mesial Temporal Lobe Seizures in Alzheimer's Disease

Frontiers in Neurology, 2019
Silent seizures were discovered in mouse models of Alzheimer's disease over 10 years ago, yet it remains unclear whether these seizures are a salient feature of Alzheimer's disease in humans. Seizures that arise early in the course of Alzheimer's disease
Alice D. Lam, Alice D. Lam, Andrew J. Cole, Andrew J. Cole, Sydney S. Cash, Sydney S. Cash   +5 more
doaj   +1 more source

Temporal lobe surgery in childhood and neuroanatomical predictors of long-term declarative memory outcome

Brain : a journal of neurology, 2014
See Berg (doi:10.1093/brain/awu320) for a scientific commentary on this article. In a long-term follow-up study of children who underwent temporal lobe surgery for treatment of epilepsy, Skirrow et al.
C. Skirrow, J. H. Cross, S. Harrison, Francesca K. Cormack, W. Harkness, R. Coleman, E. Meierotto, J. Gaiottino, F. Vargha-Khadem, Torsten Baldeweg   +9 more
semanticscholar   +1 more source

Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patients [PDF]

, 2009
Voxel-based morphometry (VBM) has detected differences between brains of groups of patients with epilepsy and controls, but the sensitivity for detecting subtle pathological changes in single subjects has not been established.
Martinian, Lillian, Sisodiya, Sanjay M., John S. Duncan, Sisodiya, S.M., Mark R. Symms, Niels K. Focke, Eriksson, Sofia H., Sofia H. Eriksson, Lillian Martinian, Focke, N.K., Thom, M., Duncan, John S., Martinian, L., Duncan, J.S., Symms, Mark R., Thom, Maria, Symms, M.R., Maria Thom, Focke, Niels K., Eriksson, S.H., Sanjay M. Sisodiya   +20 more
core   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source