Results 141 to 150 of about 3,944,943 (340)

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Invasive nasal histiocytic sarcoma as a cause of epilepsy

Journal of Feline Medicine and Surgery Open Reports, 2018
Case summary A 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity.
Koen M Santifort, Ben Jurgens, Guy CM Grinwis, Ingrid Gielen, Björn P Meij, Paul JJ Mandigers   +5 more
doaj   +1 more source

Cirurgia para epilepsia do lobo temporal secundária à esclerose mesial temporal [PDF]

, 2004
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Zarpellon, Rodrigo Jacques
core  

Interictal psychosis following temporal lobe surgery: dentate gyrus pathology

, 2014
Background De novo interictal psychosis, albeit uncommon, can develop in patients following temporal lobe surgery for epilepsy. Pathological alterations of the dentate gyrus, including cytoarchitectural changes, immaturity and axonal reorganization that ...
Liu, J.Y.W., Maynard, J., Marsdon, D., Fluegel, D., Foong, J., Goc, J., Kensche, M., Thom, M., Reeves, C.   +8 more
core   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone

Frontiers in Neuroscience
IntroductionAlthough previous studies have reported associations between gonadotropins, testosterone, and Alzheimer’s disease (AD), their longitudinal relationships with cognitive decline and temporal lobe atrophy remain insufficiently characterized ...
Min Zhao, Min Zhao, Jiwei Jiang, Jiwei Jiang, Linlin Wang, Shiyi Yang, Wenyi Li, Wenyi Li, Qiwei Ren, Qiwei Ren, Huiying Zhang, Huiying Zhang, Tianlin Jiang, Tianlin Jiang, Shirui Jiang, Shirui Jiang, Junya Zhou, Junya Zhou, Jun Xu, Jun Xu   +19 more
doaj   +1 more source

Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding [PDF]

, 2002
The precise contribution of perirhinal cortex to human episodic memory is uncertain. Human intracranial recordings highlight a role in successful episodic memory encoding, but encoding-related perirhinal activation has not been observed with functional ...
Rugg, M.D., Strange, BA, Dolan, RJ, Rugg, M., Josephs, O, Dolan, R. ; https://orcid.org/, Otten, L.J., Dolan, R.J., Strange, B., Rugg, MD, Josephs, O., Strange, B.A., Otten, L., Otten, LJ   +13 more
core  

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Constellation of psychic symptoms in one patient with mesial temporal lobe epilepsy with hippocampal sclerosis and the artistic representation of the patient’s pre and post surgical experiences

Acta Neurológica Colombiana
Introduction: We describe a constellation of psychic symptoms in a professional painter with mesial temporal lobe epilepsy and hippocampal sclerosis, rarely described together in one patient, as well as the patient’s artistic representation of these ...
Reinaldo Garcia Arismendi, John Kerrison, Gustavo A Garcia-Arismendi   +2 more
doaj   +1 more source

A randomized, controlled trial of surgery for temporal-lobe epilepsy.

New England Journal of Medicine, 2001
S. Wiebe, W. Blume, J. Girvin, M. Eliasziw   +3 more
semanticscholar   +1 more source