Results 101 to 110 of about 1,257,382 (329)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Auxiliary Variables in Temporal Specifications
ACM Transactions on Design Automation of Electronic Systems, 2016 Assertion-based verification (ABV) for IP blocks given as synchronous RTL (register transfer level) descriptions has now widely gained acceptance. The challenge addressed here is ABV for systems on chip (SoC) modeled at the system level in SystemC TLM (Transactional Level Modeling).
openaire +2 more sources
Correlated Temporal and Spectral Variability [PDF]
AIP Conference Proceedings, 2007 The variability of neutron star and black hole X‐ray sources has several dimensions, because of the roles played by different important time‐scales. The variations on time scales of hours, weeks, and months, ranging from 50% to orders of magnitude, arise out of changes in the flow in the disk.
openaire +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Aging and Cancer, EarlyView.This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
A dimensionality reduction method to select the most representative daylight illuminance distributions [PDF]
, 2020 One challenge when evaluating daylight distribution is dealing with the large amount of temporal and spatial data, visualisations and variability in illuminances that are assessed in buildings.
Jakubiec, John Alstan +2 more
core
Snowpack variability across various spatio‐temporal resolutions
Hydrological Processes, 2014 AbstractHigh‐resolution snow depth (SD) maps (1 × 1 m) obtained from terrestrial laser scanner measurements in a small catchment (0.55 km2) in the Pyrenees were used to assess small‐scale variability of the snowpack at the catchment and sub‐grid scales.
López-Moreno, Juan I. +6 more
openaire +2 more sources
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Ecology and Evolution, 2019 Predator–prey relationships are important ecological interactions, affecting biotic community composition and energy flow through a system, and are of interest to ecologists and managers.
Justin M. Waraniak +2 more
doaj +1 more source