Results 121 to 130 of about 3,945,589 (324)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Neural, electrophysiological and anatomical basis of brain-network variability and its characteristic changes in mental disorders [PDF]

, 2016
Functional brain networks demonstrate significant temporal variability and dynamic reconfiguration even in the resting state. Currently, most studies investigate temporal variability of brain networks at the scale of single (micro) or whole-brain (macro)
Benjamin Becker, Guangming Lu, Jianfeng Feng, Jie Zhang, Kai Zhang, Keith M. Kendrick, Wei Cheng, Xu Lei, Ye Yao, Yicen Liu, Zhaowen Liu   +10 more
core   +1 more source

Changes in temporal variability of precipitation over land due to anthropogenic forcings

, 2017
This study investigated the anthropogenic influence on the temporal variability of annual precipitation for the period 1950–2005 as simulated by the CMIP5 models. The temporal variability of both annual precipitation amount (PRCPTOT) and intensity (SDII)
G. Konapala, A. Mishra, L. R. Leung
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Spatial and temporal variability of biogenic isoprene emissions from a temperate estuary [PDF]

, 2012
[1] Isoprene is important for its atmospheric impacts and the ecophysiological benefits it affords to emitting organisms; however, isoprene emissions from marine systems remain vastly understudied compared to terrestrial systems.
Acuña Alvarez, Arnold, Baker, Bellinger, Bonsang, Bonsang, Broadgate, Broadgate, Brotas, Claeys, Claeys, Colomb, D. A. Exton, D. J. Suggett, Dong, Environment Agency, Exton, Fall, Fehsenfeld, Gantt, Geider, Guenther, Jeffrey, Kiendler-Scharr, Kocum, Kuzma, Laothawornkitkul, Lawrence, Lerdau, Liakakou, Liss, Loivamaki, Loreto, Luo, M. Steinke, Malin, Matsunaga, McKay, Meskhidze, Milne, Monson, Moore, Müller, Ogilvie, Pacifico, Palmer, Poisson, Ritchie, Sharkey, Sharkey, Shaw, Shaw, Simeonidis, Siwko, T. J. McGenity, Thornton, Thornton, Velikova, Velikova, Vickers, Vogt, Williams, Ziemann   +62 more
core   +1 more source

Bacteriophage Distributions and Temporal Variability in the Ocean’s Interior

mBio, 2017
Bacteriophages are numerically the most abundant DNA-containing entities in the oligotrophic ocean, yet how specific phage populations vary over time and space remains to be fully explored.
Elaine Luo, F. Aylward, D. Mende, E. Delong   +3 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Spatial and temporal variability of rainfall and their effects on hydrological response in urban areas - A review

, 2016
In urban areas, hydrological processes are characterized by high variability in space and time, making them sensitive to small-scale temporal and spatial rainfall variability.
E. Cristiano, M. Veldhuis, N. Giesen
semanticscholar   +1 more source

Long-term spatial-temporal trends and variability of rainfall over Eastern and Southern Africa

Theoretical and Applied Climatology, 2018
This study investigates the spatial-temporal trends and variability of rainfall within East and South Africa (ESA) region. The newly available Climate Hazards group Infrared Precipitation with Stations (CHIRPS-v2) gridded data spanning 37 years (1981 to ...
F. Muthoni, V. Odongo, J. Ochieng, E. Mugalavai, S. Mourice, Irmgard Hoesche-Zeledon, M. Mwila, M. Bekunda   +7 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source