Results 191 to 200 of about 17,687,317 (317)
TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss
Advanced Science, EarlyView.TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale +23 more
wiley +1 more source
Chelation‐Driven Dual‐Interface Regulation for Long‐Life Aqueous Zn–I2 Batteries
Advanced Science, EarlyView.Zn2+–TPEN coordination generates TPEN‐derived coordination species (TCC) that contribute to the regulation of both electrode interfaces. At the Zn anode, it creates an interfacial environment with reduced water accessibility that suppresses HER and corrosion while promoting uniform deposition; at the I2 cathode, it captures polyiodide to inhibit ...
Dong Wook Kim +10 more
wiley +1 more source
, 2009 Camptothecin (CPT) and its analogue 10-hydroxycamptothecin (HCPT) are two naturally occurring monoterpene indole alkaloids in Camptotheca acuminata. Both, CPT and HCPT show potential efficacy as anticancer and antiviral agents. Currently, there is a high
Sankar-Thomas, Yantree Devi
core
Mechanically Reprogrammed Coaxial Fibers for Multiphysics Transduction and Human‐Machine Interfaces
Advanced Science, EarlyView.A continuously wet‐spun coaxial fiber is developed to combine stretchable conductivity, resistive sensing, and self‐powered triboelectric sensing in a single architecture. A mechanically reprogrammed dual‐network sheath stabilizes large deformation and improves signal reliability. These fibers can be woven into textile interfaces for multichannel touch
Xinyi Cao +6 more
wiley +1 more source
Advanced Science, EarlyView.A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu +13 more
wiley +1 more source
Advanced Science, EarlyView.Permanent oxidative dipole (POD) engineering overcomes the electronic uniformity of quinoline‐linked COFs. By enhancing the dipole moment to 2.08 D and lowering exciton binding energy to 20.3 meV, it constructs a robust built‐in electric field and spatially decoupled redox centers. This bypasses inherent kinetic bottlenecks, achieving a 4569 µmol g−1 h−
Yong‐Quan Wu +2 more
wiley +1 more source
Advanced Science, EarlyView.Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo +6 more
wiley +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.Phenylboronic acid‐functionalized gold nanoparticles reversibly attach to cell‐surface glycans, enhancing photoporation‐mediated intracellular delivery. After irradiation, ATP competitively disrupts the boronic ester interactions and removes cell‐associated nanoparticles, markedly reducing residual gold.
Tao Lu +15 more
wiley +1 more source