Results 121 to 130 of about 19,761,198 (221)

Integrated Multi‐Omics Analysis of Human Cerebrospinal Fluid in Traumatic Spinal Cord Injury: An Exploratory Pilot Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Integrated proteomic and metabolomic profiling of human cerebrospinal fluid outlines a distinct molecular landscape of acute traumatic spinal cord injury. This exploratory analysis highlights a novel GOT2‐associated metabolic signature, involving concurrent decreases of GOT2, methionine, and 4‐acetamidobutanoic acid.
Wenkang Jiang, Yao Wang, Wei Miao, Huandong Liu, Qiujiang Qiao, Ting Jiang, Chenyan Shen, Zetian Zhou, Huilin Cheng, Ning Li   +9 more
wiley   +1 more source

Induction of tenascin-C by cyclic tensile strain versus growth factors: distinct contributions by Rho/ROCK and MAPK signaling pathways

, 2004
Expression of the extracellular matrix (ECM) protein tenascin-C is induced in fibroblasts by growth factors as well as by tensile strain. Mechanical stress can act on gene regulation directly, or indirectly via the paracrine release of soluble factors by
Sarasa-Renedo, Ana, Chiquet, Matthias, Tunç-Civelek, Vildan, Chiquet M, Tunç-Civelek V, Sarasa-Renedo A   +5 more
core   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Progenitor Timing Shapes NG2‐Glia Fate and Oligodendrocyte Differentiation

Glia, Volume 74, Issue 11, November 2026.
Developmental timing defines NG2‐glia and oligodendrocyte fate. E16 NG2‐progenitors produce large, more dispersed NG2‐glia clones. P0 progenitors show a bias toward oligodendrocyte differentiation. Temporal windows establish long‐term cortical glial heterogeneity.
Ana Cristina Ojalvo‐Sanz, Carolina Pernia‐Solanilla, Laura López‐Mascaraque   +2 more
wiley   +1 more source

Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10428-10438, November 2026.
ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao, Gabriel Chun Yin Sung, Yiwen Liang, Chenxi Li, Shiu Lun Au Yeung   +4 more
wiley   +1 more source

Kaplan- Meier analyses of overall and disease free survival curves for Tenascin-C expression in esophageal squamous cell carcinoma patients.

, 2016
Patients with Tenascin-C positive expressed in cancer cells had lower OS (A) and DFS (D) rates than those with Tenascin-C negative expression. Patients with Tenascin-C positive expression in stromal fibroblast had lower OS (B) and DFS (E) rates than ...
Hak-Min Lee (843453), Yong-Xue Yin (843451), Yan Cui (9885), So-Young Yeo (580179), Zhao-Ting Yang (843450), Yan-Hua Xuan (843454), Zhen-Hua Lin (843452), Seok-Hyung Kim (280362)   +7 more
core   +1 more source

Analyse der Expression von Tenascin-C-Spleißdomänen im Urothelkarzinom der Harnblase [PDF]

, 2006
Gegenstand der vorliegenden Arbeit ist die Analyse der Expression von Tenascin-C-Spleißdomänen im Urothelkarzinom der Harnblase. Das extrazelluläre Matrixprotein Tenascin-C wird im Verlauf von Gewebsumbauprozessen in verschiedenen Isoformen exprimiert ...
Anger, Katharina
core  

Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.

, 2004
Syndecan-4 is a ubiquitously expressed heparan sulfate proteoglycan that modulates cell interactions with the extracellular matrix. It is transiently up-regulated during tissue repair by cells that mediate wound healing.
Jean E. Schwarzbauer, Kim S. Midwood, Leyla V. Valenick, Henry C. Hsia   +3 more
core   +1 more source