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Understanding and measuring mechanical signals in the tumor stroma [PDF]

FEBS Open Bio
The tumor microenvironment (TME) is well known for its immune suppressive role, especially in solid tumors which are characterized by a thick, dense stroma. Apart from cell–cell interactions and biochemical signals, the tumor stroma is also characterized
Fàtima de laJara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
doaj   +3 more sources

Decoding tumor–stroma interactions: from molecular crosstalk to therapeutic targets [PDF]

FEBS Open Bio
With this “In the Limelight: Tumor‐Stroma Interactions” special issue, FEBS Open Bio aims to highlight the relevance of the tumor stroma cells, and their interactions with the tumor cells, in the progression of cancer.
Isabel Fabregat
doaj   +2 more sources

Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method

Pharmaceuticals
Background: Tumors, as intricate ecosystems, comprise oncocytes and the highly dynamic tumor stroma. Tumor stroma, representing the non-cancerous and non-cellular composition of the tumor microenvironment (TME), plays a crucial role in oncogenesis and ...
Zhi-Gang Cai, Xiao-Feng Shan, Shang Xie
exaly   +3 more sources

Tumor–stroma ratio in colitis-associated colorectal cancer [PDF]

Upsala Journal of Medical Sciences
High stroma content, as measured by tumor-stroma ratio (TSR), is generally a negative prognostic parameter for epithelial cancers, including sporadic colorectal cancer (sCRC).
Kajsa Björner, Miklos Gulyas, Per M. Hellström, Dominic-Luc Webb   +3 more
doaj   +2 more sources

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

OncoImmunology, 2023
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic ...
Iria Fernandez Botana, Giulia Pagano, Etienne Moussay, Jerome Paggetti   +3 more
doaj   +1 more source

Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

OncoImmunology, 2022
Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized.
Ernesto Gargiulo, Elodie Viry, Etienne Moussay, Jerome Paggetti   +3 more
doaj   +1 more source

Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes [PDF]

Archive of Oncology, 2022
Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series ...
Souza Da Silva Ricella M., Queiroga Eduardo M., de Toledo Osório Cynthia A.B., Cunha Karin S., Dias Eliane P.   +4 more
doaj   +1 more source

Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia

Haematologica, 2023
Chronic lymphocytic leukemia (CLL) cells are highly dependent on interactions with the immunosuppressive tumor microenvironment (TME) for survival and proliferation.
Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M. Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G. Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti   +16 more
doaj   +1 more source

Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies

Frontiers in Oncology, 2020
Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released by every cell of an organism, found in all biological fluids, and commonly involved in cell-to-cell communication through the transfer of cargo materials such as ...
Ernesto Gargiulo, Pablo Elías Morande, Pablo Elías Morande, Anne Largeot, Etienne Moussay, Jérôme Paggetti   +5 more
doaj   +1 more source

The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives

Frontiers in Oncology, 2023
Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard ...
Ernesto Gargiulo, Ernesto Gargiulo, Ernesto Gargiulo, Mirta Giordano, Carsten U. Niemann, Carsten U. Niemann, Etienne Moussay, Jérôme Paggetti, Pablo Elías Morande, Pablo Elías Morande   +9 more
doaj   +1 more source