Results 41 to 50 of about 1,355,842 (299)

Epithelial Tumor, Invasion and Stroma [PDF]

Annals of Dermatology, 2011
Uncontrolled proliferation is a defining feature of the malignant phenotype. Nevertheless, the supportive network provided by the stroma is indispensable for further invasion, progression and metastasis of cancer cells. In addition, the role of inflammation in tumorigenesis is now generally accepted, and it has become evident that an inflammatory ...
openaire   +2 more sources

Prognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancer

OncoImmunology, 2021
OX40 (CD134) is a co-stimulatory molecule mostly expressed on activated T lymphocytes. Previous reports have shown that OX40 can be an immuno-oncology target and a clinical biomarker for cancers of various organs.
Hiroshi Yokouchi, Hiroshi Nishihara, Toshiyuki Harada, Toraji Amano, Takayuki Ohkuri, Shigeo Yamazaki, Hajime Kikuchi, Satoshi Oizumi, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Masaharu Nishimura, Hiroyuki Suzuki, Hirotoshi Dosaka-Akita, Hiroshi Isobe   +23 more
doaj   +1 more source

Therapeutic Targeting of the Colorectal Tumor Stroma [PDF]

Gastroenterology, 2020
Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors.
Fridman, Wolf H, Miller, Ian, Sautès-Fridman, Catherine, Byrne, Annette T   +3 more
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Tumor-stroma signaling.

, 2016
A schematic view of the tumor-stroma signaling described below, and quantified in Tables 10–19.
Andrew Sundstrom (2616988), Dafna Bar-Sagi (2435161), Bud Mishra (66904)   +2 more
core   +1 more source

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

Cell Reports, 2015
During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood.
Yaiza del Pozo Martin, Danielle Park, Anassuya Ramachandran, Luigi Ombrato, Fernando Calvo, Probir Chakravarty, Bradley Spencer-Dene, Stefanie Derzsi, Caroline S. Hill, Erik Sahai, Ilaria Malanchi   +10 more
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The Role of tumor stroma in Cancer progression

, 2021
This thesis explores the role of components of the tumor associated stroma, with particular focus on immune cells and their role in propagating cancer progression.
Siddiqui, Ridah
core  

Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy

, 2022
The tumor stroma, which comprises stromal cells and non-cellular elements, is a critical component of the tumor microenvironment (TME). The dynamic interactions between the tumor cells and the stroma may promote tumor progression and metastasis and ...
Gabriele Toietta, Baldari, Silvia, Paola Nisticò, Nisticò, Paola, Di Modugno, Francesca, Toietta, Gabriele, Silvia Baldari, Francesca Di Modugno   +7 more
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Systems analysis of a mouse xenograft model reveals annexin A1 as a regulator of gene expression in tumor stroma. [PDF]

PLoS ONE, 2012
Annexin A1 is a multi functional molecule which is involved in inflammation, innate and adaptive immune systems, tumor progression and metastasis. We have previously showed the impaired tumor growth, metastasis, angiogenesis and wound healing in annexin ...
Ming Yi
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A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia

Frontiers in Immunology, 2022
Regulatory T cells (Tregs) are capable of inhibiting the proliferation, activation and function of T cells and play an important role in impeding the immune response to cancer.
Agnieszka Goral, Malgorzata Firczuk, Klaudyna Fidyt, Marta Sledz, Francesca Simoncello, Karolina Siudakowska, Giulia Pagano, Etienne Moussay, Jérôme Paggetti, Patrycja Nowakowska, Stefania Gobessi, Joanna Barankiewicz, Aleksander Salomon-Perzynski, Federica Benvenuti, Dimitar G. Efremov, Przemyslaw Juszczynski, Ewa Lech-Maranda, Angelika Muchowicz   +17 more
doaj   +1 more source

The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts [PDF]

, 2009
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
core