Results 21 to 30 of about 1,355,842 (299)
Tumour–stroma interactions in an organotypic culture model of pancreatic cancer [PDF]
, 2011 PhDPancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the ...
Froeling, Fieke E.M.
core +4 more sources
In Vitro Sensitivity to Venetoclax and Microenvironment Protection in Hairy Cell Leukemia
Frontiers in Oncology, 2021 Current standard treatment of patients with hairy cell leukemia (HCL), a chronic B-cell neoplasia of low incidence that affects the elderly, is based on the administration of purine analogs such as cladribine.
Alexia Vereertbrugghen +20 more
doaj +1 more source
Shed proteoglycans in tumor stroma [PDF]
Cell and Tissue Research, 2016 Cancer cell behavior is not only governed by tumor cell-autonomous properties but also by the surrounding tumor stroma. Cancer-associated fibroblasts, blood vessels, immune cells and the extracellular matrix of the tumor microenvironment have a profound influence on tumor progression.
Piperigkou, Zoi +3 more
openaire +2 more sources
Genomic Alterations in Tumor Stroma [PDF]
Cancer Research, 2009 Abstract It was traditionally believed that the tumor was the seed that lay in the passive soil of the microenvironment, with the latter providing “permissive elements” for the tumor to grow and invade. Subsequently, it was recognized that both neoplasia and its microenvironment interacted as equal partners.
Charis, Eng +3 more
openaire +2 more sources
Prostate Cancer Tumor Stroma: Responsibility in Tumor Biology, Diagnosis and Treatment [PDF]
, 2022 Prostate cancer (PCa) is a common cancer among males globally, and its occurrence is growing worldwide. Clinical decisions about the combination of therapies are becoming highly relevant.
Eiro, Noemi +23 more
core +1 more source
Tenascins : prominent molecules in tumor stroma [PDF]
, 2007 A very special connective tissue surrounds and interweaves solid tumors, the tumor stroma. Initially thought to only have a passive role, there is now more and more evidence accumulating that the tumor stroma plays an active function in the process of ...
Degen, Martin
core +1 more source
Stroma: Tumor Agonist or Antagonist [PDF]
Cell Cycle, 2005 Extensive research has been conducted over several decades understanding the genetic changes that occur in normal cells to promote them towards a transformed state. However, it is becoming increasingly apparent that carcinoma growth requires more complex interactions for development and progression.
David A, Proia, Charlotte, Kuperwasser
openaire +2 more sources
The B-side of Cancer Immunity: The Underrated Tune
Cells, 2019 Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined.
Anne Largeot +4 more
doaj +1 more source
Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice. [PDF]
PLoS ONE, 2012 INTRODUCTION: Stroma cells and extracellular matrix (ECM) components provide the pivotal microenvironment for tumor development. The study aimed to evaluate the importance of the pancreatic stroma for tumor development.
Itai Spector +5 more
doaj +1 more source
Current Oncology, 2021 The present study aimed to elucidate the clinicopathological significance and prognostic implications of tumor–stroma ratio (TSR) in colorectal cancers (CRCs). TSRs were investigated in 266 human CRC specimens.
Guhyun Kang +3 more
doaj +1 more source