Results 11 to 20 of about 1,355,842 (299)
Components of the hematopoietic compartments in tumor stroma and tumor-bearing mice. [PDF]
PLoS ONE, 2011 Solid tumors are composed of cancerous cells and non-cancerous stroma. A better understanding of the tumor stroma could lead to new therapeutic applications.
HoangDinh Huynh +8 more
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Tumor Rejection by Disturbing Tumor Stroma Cell Interactions [PDF]
The Journal of Experimental Medicine, 2001 The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10.
Ibe, S. +4 more
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Stroma-derived miR-214 coordinates tumor dissemination [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Tumor progression is based on a close interaction between cancer cells and Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated Fibroblasts (CAFs), Mesenchymal Stem Cells (MSCs) and microRNAs (miRs) play in breast ...
Francesca Orso +18 more
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Reprogramming the Tumor Stroma: A New Paradigm [PDF]
Cancer Cell, 2014 A recent article in Cell shows that vitamin D receptor activation reprograms reactive stroma in the tumor microenvironment to a less inflammatory, quiescent state and is associated with increased drug retention, tumor response, and survival in pancreatic cancer models. Stroma reprogramming, as opposed to ablation, may emerge as a new treatment paradigm.
Rowley, David R.
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Cell Cycle, 2013 Recent advances in cancer research has revealed that tumors should be considered as an integrated network of neoplastic and ancillary cells of the tumor microenvironment, including cancer- associated fibroblasts (CAFs), macrophages, endothelial cells, etc.1 The cross-talk between these populations is not only merely mediated by soluble cytokines and ...
CIRRI, PAOLO, CHIARUGI, PAOLA
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Tumor–stroma interactions [PDF]
Current Opinion in Genetics & Development, 2005 The importance of stromal cells and the factors that they express during cancer initiation and progression has been highlighted by recent literature. The cellular components of the stroma of epithelial tissues are well-recognized as having a supportive role in carcinogenesis, where the initiating mutations of a tumor originate in the epithelial cells ...
Neil A, Bhowmick, Harold L, Moses
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The fibrotic tumor stroma [PDF]
Journal of Clinical Investigation, 2018 Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical forces and create a biochemical milieu that, together, shape intratumoral immunity and influence tumor cell metastatic behavior.
Mitsuo, Yamauchi +3 more
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Tumor-stroma type and tumor-stroma ratio predict neoadjuvant chemotherapy response in breast cancer. [PDF]
Rev Assoc Med Bras (1992)OBJECTIVE: Breast cancer is the most common cancer type among women. One of the most important parameters in the prognosis of patients is the response to neoadjuvant chemotherapy.
Okcu O +6 more
europepmc +2 more sources
Frontiers in Immunology, 2020 In the past 20 years, the interest for the tumor microenvironment (TME) has exponentially increased. Indeed, it is now commonly admitted that the TME plays a crucial role in cancer development, maintenance, immune escape and resistance to therapy.
Susanne Gonder +11 more
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The Role of Stroma in Tumor Development [PDF]
The Cancer Journal, 2015 The tumor microenvironment plays an essential role in various stages of cancer development. This environment, composed of the extracellular matrix, fibroblasts, endothelial cells, and cells of the immune system regulates the behavior of and co-evolve with tumor cells.
Werb, Zena, Lu, Pengfei
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