Results 61 to 70 of about 62,717 (282)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Do Competition and Ownership Matter? Evidence from Local Public Transport in Europe [PDF]
This paper investigates how the ownership and the procedure for the selection of firms operating in the local public transport sector affect their productivity.
Andrea Boitani +2 more
core +3 more sources
The impact of contractor selection method on transaction costs: a review [PDF]
, 1998 The basic premise of transaction-cost theory is that the decision to outsource, rather than to undertake work in-house, is determined by the relative costs incurred in each of these forms of economic organization.
Chinyio, Ezekiel +2 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
E3S Web of Conferences, 2018 Selection a contractor in e-tendering procurement of goods and service is an routine activity at tenders of Central Kalimantan government. It task is doing the selection against the contractors of e-tendering that offer documents are uploaded on the ...
Amalia Citra, Setyohadi Djoko Budiyanto
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
“To Bid or Not to Bid, This is the Question: The Italian Experience in Competitive Tendering for Local Bus Services” [PDF]
Competitive tendering is a popular mechanism for the provision of local bus services when a major objective is subsidy savings. Despite uncertainties in the legal rules some competitive tendering was implemented in Italy since 1998.
Boitani, Andrea, Cambini, Carlo
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Impact of Contracting Out on the Costs of Refuse Collection Services - The Case of Ireland [PDF]
This paper examines the impact of contracting out on the costs incurred by local authorities in providing refuse collection services. Using original survey data for the Republic of Ireland, three methods of estimating the impact of tendering are adopted.
Eoin Reeves, Michael Barrow
core