Results 81 to 90 of about 62,717 (282)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Construction contractor prequalification from polish clients’ perspective
Journal of Civil Engineering and Management, 2010 A competent construction contractor is one of the indispensable conditions of a proper process and completion of a construction project. The article presents analysis results of the main criteria considered by Polish public clients in contractor ...
Edyta Plebankiewicz
doaj
The Scientific World Journal, 2014 The recent government tendering process being conducted in an electronic way is becoming an inevitable affair for numerous governmental agencies to further exploit the superiorities of conventional tendering.
Yan Wang +5 more
doaj +1 more source
Competitive tendering in the Scottish National Health Service Was it compulsory, and did it make a difference?(*) [PDF]
This paper examines the implementation of competitive tendering in the Scottish National Health Service. Data relating to cleaning, catering and laundering services-- the three services targeted for competitive tendering--are examined.
Robin Milne, Robin Wright
core
Replacing CCT with “best value” [PDF]
, 1999 Professor Christopher Bovis (University of Central Lancashire) assesses the concept of best value in delivering public services, following the demise of the compulsory competitive tendering (CCT) regime. He compares it with its predecessor and elaborates
Bovis, Christopher H.
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Actual problems of the antimonopoly requirements` observance in the bidding for the sale of land in the Russian Federation [PDF]
Eastern Journal of European Studies, 2013 A comprehensive view of the topic of Antimonopoly regulation in the sphere of land auctions for the Russian legal science and legal science other Eastern European countries is highly relevant.
Alexey Pavlovich ANISIMOV +2 more
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source