Results 61 to 70 of about 379,513 (362)

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Stem Cell Research & Therapy
Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a ...
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger   +9 more
doaj   +1 more source

A distinct transition from cell growth to physiological homeostasis in the tendon

eLife, 2019
Changes in cell proliferation define transitions from tissue growth to physiological homeostasis. In tendons, a highly organized extracellular matrix undergoes significant postnatal expansion to drive growth, but once formed, it appears to undergo little
Mor Grinstein, Heather L Dingwall, Luke D O'Connor, Ken Zou, Terence Dante Capellini, Jenna Lauren Galloway   +5 more
doaj   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Influence of kilohertz frequency, burst duty cycle and burst duration on evoked torque, discomfort and muscle efficiency: A randomized crossover trial

Physiological Reports
Kilohertz‐frequency alternating currents (KFACs) have been indicated to minimize muscle atrophy and weakness. However, the optimal stimulation parameters still need to be determined.
Karenina Arrais Guida Modesto, Priscila Karen Silva Raposo, Isabella da Silva Almeida, Marco Aurélio Vaz, João Luiz Quagliotti Durigan   +4 more
doaj   +1 more source

Tuberculous Peroneal Tenosynovitis

Journal of Orthopaedics, Trauma and Rehabilitation, 2016
Musculoskeletal tuberculosis accounts for 1–5% of all cases of tuberculosis. Tuberculous tenosynovitis is an uncommon form of musculoskeletal tuberculosis occurring primarily in the hands and wrists and is rarely reported in the tendons of the feet.
Yu Chung Wong, Tun Hing Lui
doaj   +1 more source

The Ruptured Achilles Tendon Elongates for 6 Months After Surgical Repair Regardless of Early or Late Weightbearing in Combination With Ankle Mobilization: A Randomized Clinical Trial

American Journal of Sports Medicine, 2018
Background: Treatment strategies for Achilles tendon rupture vary considerably, and clinical outcome may depend on the magnitude of tendon elongation after surgical repair.
P. Eliasson, A. Agergaard, C. Couppé, R. Svensson, Rikke Hoeffner, S. Warming, Nichlas Warming, C. Holm, M. Jensen, M. Krogsgaard, M. Kjaer, S. Magnusson   +11 more
semanticscholar   +1 more source

Time trends and predictors of gout remission over six years

Arthritis Care &Research, Accepted Article.
Objectives This study aims to describe the trends in remission rates over six years of follow‐up among people with gout taking urate‐lowering therapy (ULT), and to identify variables that predict remission. Methods A post hoc analysis was conducted using data from the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Greg Gamble, Lisa K Stamp, William J Taylor, Nicola Dalbeth   +5 more
wiley   +1 more source

Update of contrast-enhanced ultrasound in musculoskeletal medicine: Clinical perspectives – A review

Journal of Medical Ultrasound, 2023
Contrast-enhanced ultrasound (CEUS) uses an intravascular contrast agent to enhance blood flow signals and assess microcirculation in different parts of the human body.
Shao-Yu Chen, Yao-Wei Wang, Wen-Shiang Chen, Ming-Yen Hsiao   +3 more
doaj   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source