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Strategies for promoting tendon-bone healing: Current status and prospects [PDF]

open access: goldFrontiers in Bioengineering and Biotechnology, 2023
Tendon-bone insertion (TBI) injuries are common, primarily involving the rotator cuff (RC) and anterior cruciate ligament (ACL). At present, repair surgery and reconstructive surgery are the main treatments, and the main factor determining the curative ...
Chenhui Yang   +24 more
doaj   +3 more sources

The Functions and Mechanisms of Tendon Stem/Progenitor Cells in Tendon Healing

open access: yesStem Cells International, 2023
Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics and is characterized by pain and limitation of joint function.
Jingwei Lu   +8 more
doaj   +2 more sources

Reparative and Maladaptive Inflammation in Tendon Healing

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in ...
Varun Arvind   +2 more
doaj   +2 more sources

A Promising Candidate in Tendon Healing Events—PDGF-BB

open access: yesBiomolecules, 2022
Tendon injuries are one of the most common musculoskeletal disorders for which patients seek medical aid, reducing not only the quality of life of the patient but also imposing a significant economic burden on society.
Yixuan Chen   +7 more
doaj   +2 more sources

Regulating Macrophages through Immunomodulatory Biomaterials Is a Promising Strategy for Promoting Tendon-Bone Healing

open access: yesJournal of Functional Biomaterials, 2022
The tendon-to-bone interface is a special structure connecting the tendon and bone and is crucial for mechanical load transfer between dissimilar tissues.
Haihan Gao   +11 more
doaj   +2 more sources

The Roles of MicroRNAs in Tendon Healing and Regeneration

open access: yesFrontiers in Cell and Developmental Biology, 2021
Tendons connect the muscle abdomen of skeletal muscles to the bone, which transmits the force generated by the muscle abdomen contraction and pulls the bone into motion.
Lingli Ding   +3 more
doaj   +2 more sources

The Role of Vascular Endothelial Growth Factor in Tendon Healing

open access: yesFrontiers in Physiology, 2021
Angiogenesis is crucial to facilitate tendon healing, such as delivering oxygen and nutrients, removing waste products, and controlling immune responses.
Xueli Liu   +8 more
doaj   +2 more sources

Challenges in tendon–bone healing: emphasizing inflammatory modulation mechanisms and treatment

open access: yesFrontiers in Endocrinology
Tendons are fibrous connective tissues that transmit force from muscles to bones. Despite their ability to withstand various loads, tendons are susceptible to significant damage.
Fan Jiang   +12 more
doaj   +2 more sources

Tendon healing is adversely affected by low-grade inflammation [PDF]

open access: goldJournal of Orthopaedic Surgery and Research, 2021
Background Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and
Emanuele Chisari   +3 more
openalex   +2 more sources

Biology and physiology of tendon healing

open access: yesJoint Bone Spine
Tendon disorders affect people of all ages, from elite and recreational athletes and workers to elderly patients. After an acute injury, 3 successive phases are described to achieve healing: an inflammatory phase followed by a proliferative phase, and finally by a remodeling phase.
Darrieutort-Laffite, Christelle   +3 more
openaire   +5 more sources

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