Results 181 to 190 of about 7,099 (210)

The Use of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide for Preventing Vertical Transmission of Hepatitis B

Journal of Clinical Gastroenterology, 2022
Background: Mother-to-child transmission (MTCT) of hepatitis B virus may occur in highly viremic mothers despite the infants receiving appropriate immunoprophylaxis. We aimed to review tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) data for preventing MTCT. Methods and Data
Lin, Zhu, Jaimie, Park, You, Deng, Calvin Q, Pan   +3 more
openaire   +2 more sources

Population Pharmacokinetics of Tenofovir Alafenamide Fumarate and Its Metabolite Tenofovir in Healthy Chinese Volunteers

Clinical Pharmacology in Drug Development, 2023
AbstractTenofovir alafenamide fumarate (TAF) is a first‐line drug for treating hepatitis B virus infection. This study aimed to establish the prodrug–metabolite population pharmacokinetic (PK) model for TAF and its metabolite tenofovir (TFV) in healthy Chinese volunteers and evaluate the factors affecting the PK.
Xingfang, Ji, Yunfei, Li, Zhipeng, Wang, Yuan, Gao, Ling, Wang   +4 more
openaire   +2 more sources

Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate are not transported by Concentrative Nucleoside Transporter 2

Diagnostic Microbiology and Infectious Disease, 2019
Tenofovir-associated renal toxicity is influenced by several factors, including plasma exposure and genetic variants in transporter-encoding genes. Tenofovir plasma exposure has been associated with a polymorphism in SLC28A2 gene (encoding the concentrative nucleoside transporter 2, CNT2): particularly, SLC28A2 124 CT/TT genotype patients show higher ...
Cusato J., Calcagno A., De Nicolo A., Mogyorosi K., D'Avolio A., Di Perri G., Bonora S.   +6 more
openaire   +2 more sources

[Tenofovir alafenamide fumarate - a new generation of tenofovir].

Klinicka mikrobiologie a infekcni lekarstvi, 2018
Antiretroviral therapy as a life-long treatment has to meet the criteria of maximum efficiency while maintaining the highest possible level of safety and tolerance. Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug with an excellent effect of virological suppression.
Svatava, Snopková, Kateřina, Havlíčková, Petr, Husa   +2 more
openaire   +1 more source

Tenofovir alafenamide is associated with improved alanine aminotransferase and renal safety compared to tenofovir disoproxil fumarate

Journal of Medical Virology, 2022
AbstractTenofovir alafenamide (TAF) is a novel prodrug of tenofovir for the treatment of chronic hepatitis B (CHB) infection. We aimed to evaluate the impact of switching to TAF on alanine aminotransferase (ALT) normalization and renal safety. We also described the indications of switching to TAF.
Lilian Yan Liang, Terry Cheuk‐Fung Yip, Jimmy Che‐To Lai, Amy Shuk‐Man Lam, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Henry Lik‐Yuen Chan, Vincent Wai‐Sun Wong, Grace Lai‐Hung Wong   +8 more
openaire   +2 more sources

Tenofovir Alafenamide Fumarate Therapy for HIV Treatment: Cardiometabolic and Renal Safety

AIDS Research and Human Retroviruses, 2020
Antiretroviral treatment based on tenofovir alafenamide fumarate (TAF) is increasingly recommended, as it maintains the viral suppression and improves renal function and bone density in comparison with tenofovir disoproxil fumarate (TDF). We carried out a retrospective cohort study including experienced patients who switched treatment from TDF to TAF ...
Vasilis, Petrakis, Periklis, Panagopoulos, Stella, Papachristou, Nikolaos, Papanas, Irene, Terzi, Grigorios, Trypsianis, Dimitrios, Papazoglou   +6 more
openaire   +2 more sources

Tenofovir alafenamide compared to tenofovir disoproxil fumarate, induces dysglycemia, and dyslipidemia in Wistar rats

AIDS
Objectives: To determine the metabolic effects of tenofovir alafenamide (TAF) compared to tenofovir disoproxil fumarate (TDF) in vivo. Design and methods: Male Wistar rats (Rattus novergicus, 250–300 g body weight) were divided into three groups (n = 8) and orally treated daily with
Rajendraparsad, Hurchund, Sinegugu E, Sibiya, Bernard O, Owaga, Peter M O, Owira   +3 more
openaire   +2 more sources

Emtricitabine/tenofovir alafenamide/emtricitabine/tenofovir disoproxil fumarate

Reactions Weekly, 2021
openaire   +1 more source

Dolutegravir/emtricitabine/tenofovir-alafenamide/tenofovir-disoproxil-fumarate

Reactions Weekly, 2022
openaire   +1 more source

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial

Lancet, The, 2021
Shahin Lockman, Lauren Ziemba, Lynda Stranix-Chibanda   +2 more
exaly