Results 21 to 30 of about 12,401 (156)

Reverse phase-liquid chromatography assisted protocol for simultaneous determination of lamivudine and tenofovir disoproxil fumarate in combined medication used to control HIV infection: an investigative approach

Future Journal of Pharmaceutical Sciences, 2021
Background Human immunodeficiency virus (HIV) causes severe life-threatening condition, i.e., AIDS. HIV destabilises an individual’s ability to prevent infection.
Vaibhav S. Adhao, Suraj R. Chaudhari, Jaya P. Ambhore, Sunil Sangolkar, Raju R. Thenge, Rameshwar S. Cheke, Amod S. Patil   +6 more
doaj   +1 more source

Impact of treatment adherence on efficacy of dolutegravir plus lamivudine and dolutegravir plus tenofovir disoproxil fumarate/emtricitabine: pooled analysis of the GEMINI-1 and GEMINI-2 clinical studies

HIV Research & Clinical Practice, 2021
Background: GEMINI-1 and GEMINI-2 (ClinicalTrials.gov, NCT02831673 and NCT02831764, respectively) are double-blind, multicenter, phase III studies that demonstrated the non-inferiority of once-daily dolutegravir + lamivudine to dolutegravir + tenofovir ...
Mounir Ait-Khaled, Juan Sierra Madero, Vicente Estrada, Roberto Gulminetti, Debbie Hagins, Hung-Chin Tsai, Choy Man, Jörg Sievers, Richard Grove, Andrew Zolopa, Brian Wynne, Jean van Wyk   +11 more
doaj   +1 more source

Fanconi syndrome, diabetes insipidus, and acute kidney injury due to tenofovir disoproxil fumarate: A case report

Antiviral Therapy, 2023
Background Tenofovir disoproxil fumarate is widely used in Botswana as part of the first-line antiretroviral regimen in the ‘Treat All’ strategy implemented in 2016 by the Ministry of Health.
Nthabiseng Zilwa, Onalethata Mpejane, Golam Mehboob, Sajan Gill, Thomas Kalinoski   +4 more
doaj   +1 more source

The evidence for using tenofovir disoproxil fumarate plus lamivudine as a nucleoside analogue backbone for the treatment of HIV

Journal of Virus Eradication, 2021
This article evaluates the evidence supporting use of the tenofovir disoproxil fumarate (TDF) plus lamivudine (3​TC) combination as a dual nucleoside backbone within a triple drug antiretroviral regimen.
Laura Waters, Viraj Mehta, Jaideep Gogtay, Marta Boffito   +3 more
doaj   +1 more source

A case of fatal acute kidney failure and anion gap metabolic acidosis in human immunodeficiency virus patient receiving tenofovir disoproxil fumarate

Heliyon
Tenofovir disoproxil fumarate, is the prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitors used to treat human immunodeficiency virus infection. Tenofovir disoproxil fumarate is the antiretroviral most associated with acute kidney
Nata Pratama Hardjo Lugito, Margaret Merlyn Tjiang, Jeremia Immanuel Siregar, Raoulian Irfon, Andhica Saputri   +4 more
doaj   +1 more source

Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Birthday

Molecules, 2021
Nucleoside and nucleotide analogues are essential antivirals in the treatment of infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), varicella-zoster virus (VZV ...
Guangdi Li, Tingting Yue, Pan Zhang, Weijie Gu, Ling-Jie Gao, Li Tan   +5 more
doaj   +1 more source

Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review

Clinical and Experimental Obstetrics & Gynecology, 2021
Infection with the hepatitis B virus (HBV) is one of the leading global public health issues. Over 250 million people worldwide have chronic HBV infection, out of which roughly 65 million are women in their reproductive age.
Iulia Baciu, Dalila-Ana Domuncu, Tiberiu Domuncu, AncaMarina Ciobanu, Theodor Voiosu, Gheorghe Peltecu, AncaMaria Panaitescu   +6 more
doaj   +1 more source

Advancing HIV prevention using tenofovir-based pre-exposure prophylaxis

Antiviral Therapy, 2022
Tenofovir-based pre-exposure prophylaxis (PrEP) revolutionized the global HIV prevention landscape. Prior to the proof-of concept trial in 2010, which demonstrated that tenofovir (TFV) could prevent sexual transmission of HIV, prevention options were ...
Salim S Abdool Karim, Cheryl Baxter, Quarraisha Abdool Karim   +2 more
doaj   +1 more source

Guides concerning tenofovir exposure via breastfeeding: A comparison of drug dosages by developmental stage

International Journal of Infectious Diseases, 2019
Tenofovir disoproxil fumarate (TDF) is a prodrug of tenofovir, and after being administered orally, it converts to tenofovir in the blood. With the increasing use of TDF in women for treatment and prevention of mother-to-child transmission (MTCT) of both
Xiaotong Hu, Liming Wang, Fujie Xu
doaj   +1 more source

Antiviral Therapy and Post‐Resection Outcomes in Patients With Hepatitis B Virus‐Related Hepatocellular Carcinoma

Alimentary Pharmacology &Therapeutics, EarlyView.
In 902 patients with HBV‐related HCC undergoing curative resection, antiviral regimens (ETV, TDF, TAF) showed comparable recurrence‐free survival. However, TDF was independently associated with improved overall survival compared with ETV. ABSTRACT Background & Aims The comparative outcomes of entecavir (ETV), tenofovir disoproxil fumarate (TDF), and ...
Jaehong Jeong, Jung Pyo Hong, Dong Yun Kim, Jae Seung Lee, Mi Na Kim, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Hye Won Lee   +10 more
wiley   +1 more source