Results 91 to 100 of about 1,007,262 (294)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Tonic Investigation Concept of Cervico-vestibular Muscle Afferents

International Archives of Otorhinolaryngology, 2017
Introduction Interdisciplinary research has contributed greatly to an improved understanding of the vestibular system. To date, however, very little research has focused on the vestibular system's somatosensory afferents. To ensure the diagnostic quality
Linda Josephine Dorn, Annabelle Lappat, Winfried Neuhuber, Hans Scherer, Heidi Olze, Matthias Hölzl   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Deep SDSS optical spectroscopy of distant halo stars I. Atmospheric parameters and stellar metallicity distribution

, 2014
We analyze a sample of tens of thousands of spectra of halo turnoff stars, obtained with the optical spectrographs of the Sloan Digital Sky Survey (SDSS), to characterize the stellar halo population "in situ" out to a distance of a few tens of kpc from ...
Beers, T. C., Bizyaev, D., Ebelke, G., Fernandez-Alvar, E., Lee, Y. S., Malanushenko, E., Malanushenko, V., Morrison, H. L., Oravetz, D., Pan, K., Prieto, C. Allende, Robin, A. C., Schlesinger, K. J., Schneider, D. P., Simmerer, J., Simmons, A., Sobeck, J.   +16 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Remote Analgesic Effects Of Conventional Transcutaneous Electrical Nerve Stimulation: A Scientific And Clinical Review With A Focus On Chronic Pain

Journal of Pain Research, 2019
Shai N Gozani NeuroMetrix, Waltham, MA, USACorrespondence: Shai N GozaniNeuroMetrix, 1000 Winter Street, Waltham, MA 02451, USA Tel +1 781 314 2789Fax +1 781 890 1556Email gozani@neurometrix.comBackground: Transcutaneous electrical nerve stimulation ...
Gozani SN
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Blood pressure and obesity in the adult population who goes to the municipal market in Portalegre [PDF]

, 2010
A tensão arterial é considerada um dos factores de risco mais importante em diversos problemas de saúde. Por outro lado, também a obesidade é considerada um problema de saúde pública em países desenvolvidos (WHO, 2004).
Arriaga, Miguel, Cordeiro, Raul, Costa, Andreia, Louro, Olga, Martins, Mário, Miranda, António, Vidinha, Francisco   +6 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Novel Techniques to Manage Temporomandibular Disorders – A Multidisciplinary Approach

Journal of Pharmacy and Bioallied Sciences
Temporomandibular joint is a compound, bilateral, ginglymoarthroidal joint articulating the condyle to temporal glenoid fossa. TMDs often project a constellation of signs and symptoms.
Mehul A. Shah, Kunal Shankarrao Deshmukh, Kabir Suman Dash, Shafali Agrawal, Ankita Mishra, Vignesh Kamath   +5 more
doaj   +1 more source