Results 71 to 80 of about 293,584 (300)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reduced Analgesic Effect of Acupuncture-like TENS but Not Conventional TENS in Opioid-Treated Patients [PDF]
, 2011 : Evidence from recent animal studies indicates that the analgesic effect of low frequency TENS is reduced in opioid tolerant animals. The aim of the present study was to compare the analgesic effect of conventional (high frequency) and acupuncture-like
Guillaume Léonard +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2008 Introduction: Transcutaneous electrical nerve stimulation (TENS) is used to reduce pain. TENS is applied as conventional TENS (50-100 Hz, causing paraesthesia) or acupuncture-like TENS (AL-TENS).
Francis, Richard Paul
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Increasing Intensity of TENS Prevents Analgesic Tolerance in Rats
, 2012 Transcutaneous electrical nerve stimulation (TENS) reduces hyperalgesia and pain. Both low-frequency (LF) and high-frequency (HF) TENS, delivered at the same intensity (90% motor threshold [MT]) daily, result in analgesic tolerance with repeated use by ...
Sanada, Luciana S. +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effectiveness of transcutaneous electrical nerve stimulation (TENS) modality for treating myofascial pain syndrome: A systematic review and meta-analysis [PDF]
Journal of Research in Clinical MedicineIntroduction: Myofascial pain syndrome (MPS) is a prevalent chronic pain disorder that initiates from myofascial trigger points (MTrPs) in skeletal muscle.
Vahideh Toopchizadeh +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesBackground: Orthodontic treatment often induces pain, especially post appliance placement. This study compares transcutaneous electrical nerve stimulation (TENS) and acetaminophen for orthodontic pain management. Materials and Methods: A randomized trial
Mrigank Shekhar Jha +3 more
doaj +1 more source
Music Modulated TENS Therapy [PDF]
, 2018 Often, for alleviating severe pain, strong painkiller medications are administered which leads to side effects on a long term basis. In case postoperative care this prolongs surgical recovery time in turn increased hospitalization costs.
Chandurkar, Yogesh N +3 more
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