Results 61 to 70 of about 175,313 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pengaruh TENS (transcutaneus electrical nerve stimulation) terhadap intensitas nyeri pada pasien post operasi sectio caesarea

Junal Kebidanan Dan Keperawatan Aisyiyah, 2018
Ketidaknyamanan atau nyeri bagaimanapun keadaannya harus diatasi, karena kenyamanan merupakan kebutuhan dasar manusia. Penelitian ini bertujuan: untuk mengetahui pengaruh TENS (Transcutaneus Electrical Nerve Stimulation) terhadap intensitas nyeri pada ...
Agus Sarwo Prayogi, Yeyen Yuliana, Ana Ratnawati   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Remote Analgesic Effects Of Conventional Transcutaneous Electrical Nerve Stimulation: A Scientific And Clinical Review With A Focus On Chronic Pain

Journal of Pain Research, 2019
Shai N Gozani NeuroMetrix, Waltham, MA, USACorrespondence: Shai N GozaniNeuroMetrix, 1000 Winter Street, Waltham, MA 02451, USA Tel +1 781 314 2789Fax +1 781 890 1556Email gozani@neurometrix.comBackground: Transcutaneous electrical nerve stimulation ...
Gozani SN
doaj  

Short-term Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Pain in Patients with Bone Metastasis: An Uncontrolled Pretest-Posttest Study

Siriraj Medical Journal, 2020
Objective: To evaluate the short-term effect of TENS on pain for patients with bone metastasis. Methods: An experimental descriptive study of 25 eligible advanced cancer patients with bone metastasis. Patients were enrolled in the study from June 1, 2018
Thipawan Bowornkitiwong, Wanida Seevokom, Pawinee Tawatchot, Teeraporn Paisan, Suganyapatch Sirichotpapa, Sirinya Nanthanangkul, Teerapol Sommaichaiya   +6 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative analysis of two different physiotherapy intervention programs in individuals experiencing chronic lower back pain [PDF]

Romanian Journal of Medical Practice
Background and objectives. Physiotherapy programs in individuals experiencing chronic lower back pain (CLBP) aim to improve function, disabilities from worsening. As per clinical practice guidelines, many methods are applied, such as the McKenzie method,
Sylejman MIFTARI, Shkurta RRECAJ-MALAJ, Ardiana MURTEZANI, Besnik ISMAJLI, Mejdi ALIU   +4 more
doaj   +1 more source

A Perfect Ten [PDF]

ChemSusChem, 2016
The X files: This Editorial welcomes you to Volume 10 of ChemSusChem! It contains a look at some of the statistics and highlights from 2016, as well as some of our plans for 2017. The truth is in here!
openaire   +2 more sources