Results 41 to 50 of about 593,496 (327)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
An Annotation Scheme for Reichenbach's Verbal Tense Structure [PDF]
, 2011 In this paper we present RTMML, a markup language for the tenses of verbs and temporal relations between verbs. There is a richness to tense in language that is not fully captured by existing temporal annotation schemata. Following Reichenbach we present
Derczynski, Leon, Gaizauskas, Robert
core +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
PERNYATAAN KALA DAN ASPEK DALAM BAHASA ARAB: ANALISIS SEMANTIK VERBA
Arabi: Journal of Arabic Studies, 2018 This research was a qualitative research using structural linguistic method. The findings showed that the conjugation of the perfect verbs (ma>dhi) into imperfect verbs (mudha>ri’) can reveal the concept of semantic time and aspect. It was found that the
Tajudin Nur
doaj +1 more source
PAST-TIME REFERENCE, TENSE, AND ASPECT PAST SIMPLE AND PRESENT PERFECT [PDF]
Studies in Linguistics, Culture, and FLT, 2018 Stemming from the most common errors in the use of English tenses by Bulgarian learners, the article deals with the comparison and contrast between the Past Simple and the Present Perfect as special attention is paid to their temporal and aspectual ...
Miroslava Tsvetkova
doaj +1 more source
European Journal of Cardio-Thoracic Surgery, 2020 Abstract We report a case of prosthesis dislodgement after transcatheter mitral valve replacement in an 85-year-old woman with chronic ischaemic heart failure. Two weeks after an initial successful implantation, she presented with a paravalvular leak associated with left ventricular outflow tract obstruction.
Daniel Grinberg +3 more
openaire +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
A DESCRIPTIVE STUDY ON THE SECOND YEAR STUDENTS' ERRORS IN ENGLISH WRITTING AT SMP 1 DUNGKEK SUMENEP IN ACADEMIC YEAR 2005 / 2006 [PDF]
, 2006 The writer was interested in analyzing the errors made by the second year students of SMP 1 Dungkek, Sumenep because of two reasons : First, the students often make errors, when they wrote an essay, at although they had been given the topic before by the
WAHYUNI, SRI
core
On the relation between modality and tense [PDF]
, 2019 We critically review two extant paradigms for understanding the systematic interaction between modality and tense, as well as their respective modifications designed to do justice to the contingency of time’s structure and composition.
Correia, Fabrice, Rosenkranz, Sven
core +3 more sources