Results 141 to 150 of about 883,383 (317)

The stress-strain state of cylindrical sample from alloy D16T under axial tension and torsion creep

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2013
The method for calculation of cylindrical sample rheological deformation and fracture in creep conditions for three types of stress state: tension, pure torsion, the combined effect of tensile load and torque is offered.
Vladimir P Radchenko, Vitaliy V Tsvetkov
doaj  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Surface Tension Matthew Buckingham, Nina Canell & Robin Watkins, Youngmi Chun, Kelly Jazvac, Sreshta Rit Premnath, Jimmy Robert, Mark Soo

, 2013
Over the past decade, digital media has transformed how we take pictures, how existing images circulate in the world and how histories are written. While many artists have questioned where to locate images in our contemporary context, their ongoing ...
Jazvac, Kelly, Buckingham, Matthew, Soo, Mark, Canell & Watkins, Nina & Robin, Korczynski, Jacob,, Premnath, Sreshta Rit, Chun, Youngmi, Robert, Jimmy, Lund University.   +8 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Convertisseur de tension DC/DC muni d’un dispositif coupe-circuit

, 2019
Convertisseur de tension DC/DC muni d’un dispositif coupe-circuit Convertisseur de tension (10) comportant au moins un bras (24) s’étendant entre un premier terminal continu (16) et un deuxième terminal continu (28) et comportant au moins un demi-bras ...
Dworakowski, Piotr, Paez Alvarez, Juan, Frey, David, Morel, Florent, Maneiro, Jose, Bacha, Seddik   +5 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Tension pneumocephalus 12 years after craniotomy -A Case Report- [PDF]

, 2005
We present herein the case of a 40-year-old man who experienced tension pneumocephalus 12 years after craniotomy. Subarachnoid hemorrhage due to ruptured anterior communicating artery aneurysm had resulted in clipping of the aneurysm followed by ...
諸藤, 陽一, 永田, 泉, 笠, 伸年, 出雲, 剛   +3 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source