The ultrafine-bridge-associated endonuclease ANKLE1 is stimulated by tension in DNA to process branch-points. [PDF]
Nucleic Acids ResRay KK +6 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Dual P-Values, Evidential Tension and Balanced Tests [PDF]
In the classical approach to statistical hypothesis testing the role of the null hypothesis H0 and the alternative H1 is very asymmetric. Power, calculated from the distribution of the test statistic under H1, is treated as a theoretical construct that ...
Arivalzahan Sengarapillai, D.S. Poskitt
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Analyzing the Influence of Sizing Machine Settings on the Performance of the Sized Cotton Warp Yarns Using Eco-Friendly Carboxymethyl Cellulose from Saudi Wheat Straw. [PDF]
Polymers (Basel)Maatoug S, Abu Nab E.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A sustainable yarn tension control technique for optimizing textile dyeing efficiency and water use. [PDF]
PLoS OneAhmed R, Amer M, Ismail L.
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Prospective multicentre randomised trial of tension-free vaginal tape and colposuspension as primary treatment for stress incontinence [PDF]
Objective To compare tension-free vaginal tape with colposuspension as primary treatment for stress incontinence. Design Multicentred randomised comparative trial.
Hilton P; Ward K; United Kingdom Ireland Tension Fre
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Mechanochemical bistability as a principle of robust morphogenesis. [PDF]
Mechanobiol MedXue SL.
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source