Results 71 to 80 of about 2,639,223 (300)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Influence of liquid surface tension (surfactants) on bubble formation at rigid and flexible orifices [PDF]

open access: yes, 2004
The influence of liquid surface tension on the bubble formation from both rigid and flexible orifice has been investigated. The liquid phases under test are aqueous solutions with butanol or surfactants (cationic, non-ionic and anionic); static and ...
Hebrard, Gilles, Loubière, Karine
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The First Law for Boosted Kaluza-Klein Black Holes [PDF]

open access: yes, 2007
We study the thermodynamics of Kaluza-Klein black holes with momentum along the compact dimension, but vanishing angular momentum. These black holes are stationary, but non-rotating.
B. Carter   +14 more
core   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Effect of Initial Curvature on Pipeline Bearing Capacity

open access: yesShiyou jixie, 2020
To study the influence of the initial curvature on the bearing capacity of the pipeline,a mathematical relationship between the strain energy and deformation of the cross section of the pipeline is established based on the beam theory.
Liao Hongqian
doaj  

NEW FUNCTIONAL RELATIONS FOR LINEAR RHEOLOGICAL MODELS OF MAXWELL AND KELVIN-VOIGT

open access: yesРоссийский технологический журнал, 2017
The article proposes new functional relationships for deformations and stresses within the framework of the linear rheological Maxwell and Kelvin-Vogt models.
V. D. Karlov
doaj   +1 more source

Corporate Sustainability Paradox Management: A Systematic Review and Future Agenda

open access: yesFrontiers in Psychology, 2020
Increasing evidence suggests that corporate sustainability is paradoxical in nature, as corporates and managers have to achieve economic, social, and environmental goals, simultaneously.
Ben Nanfeng Luo   +4 more
doaj   +1 more source

Coarse-Grained Simulations of Membranes under Tension

open access: yes, 2010
We investigate the properties of membranes under tension by Monte-Carlo simulations of a generic coarse-grained model for lipid bilayers. We give a comprising overview of the behavior of several membrane characteristics, such as the area per lipid, the ...
Beate West   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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