Results 91 to 100 of about 361,101 (305)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design and Analysis of a Novel Tension Control Method for Winding Machine

Chinese Journal of Mechanical Engineering, 2018
Filament winding has emerged as the main process for carbon fiber reinforced plastic (CFRP) fabrication, and tension control plays a key role in enhancing the quality of the winding products.
Xiao-Ming Xu, Wu-Xiang Zhang, Xi-Lun Ding, Ming Zhang, Shi-Hou Wei   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Homeotic compartment curvature and tension control spatiotemporal folding dynamics. [PDF]

Nat Commun, 2023
Villedieu A, Alpar L, Gaugué I, Joudat A, Graner F, Bosveld F, Bellaïche Y.   +6 more
europepmc   +1 more source

Tensions under control

, 2004
Output growth is robust in almost all areas of the world, with world GDP expected to rise by 5% in 2004 and 4% in 2005. Growth will remain buoyant in emerging Asian economies although it is expected to slightly decelerate under the effects of the recent strong increases of oil and industrial raw materials prices.
Timbeau, Xavier, Baudchon, Hélène, Chagny, Odile, Chauvin, Valerie, Chevillon, Guillaume, Dupont, Gael, Falah, Amel, Heyer, Eric, Le Bayon, Sabine, Lemoine, Matthieu, Mathieu, Catherine, Veroni, Paola, Péléraux, Hervé, Plane, Mathieu, Rifflart, Christine, Schweisguth, Danielle, Stancanelli, Elena   +16 more
openaire   +1 more source

A tension approach to controlling the shape of cubic spline surfaces on FVS triangulations

, 2009
We propose a parametric tensioned version of the FVS macro-element to control the shape of the composite surface and remove artificial oscillations, bumps and other undesired behaviour.
Manni, C, Oleg Davydov, Manni, C., Manni, Carla, Davydov, O, Davydov, Oleg, Davydov, O., Carla Manni   +7 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Flatness-Based Nonlinear Control Scheme for Wire Tension Control of Hoisting Systems

IEEE Access, 2019
A double-rope winding hoisting system (DRWHS) is usually employed to transport weight or workers in mines usually from ultra-deep underground (>1000m).
Wanshun Zang, Gang Shen, Guangchao Rui, Xiang Li, Ge Li, Yu Tang   +5 more
doaj   +1 more source