Results 131 to 140 of about 10,091 (292)

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Towards the complete classification of tent maps inverse limits [PDF]

, 2015
We study tent map inverse limits, i.e. inverse limits of inverse sequences of unit segments ▫$I$▫ with a tent map being the only bonding function. As the main result we identify an infinite family of curves in ▫$I^2$▫ such that if top points of graphs of
Banič, Iztok, Črepnjak, Matevž, Merhar, Matej, Milutinović, Uroš   +3 more
core  

Dynamics of skew tent maps

Dynamics of skew tent maps
This paper deals with the dynamical properties of so-called skew tent maps defined by \[ f_{a,b}(x)= \begin{cases} ax+1, &x\leq 0,\\ -bx+1, &x\geq 0,\end{cases} \tag{1} \] \((a,b)\in D:= \{(a,b)\mid a>0\), \(b>1\), \(a+b\geq ab\}\). Here the authors give the relation between \(*\)-product for a kneading sequence and renormalization.
Ichimura, Keiko, Ito, Michiho
openaire   +3 more sources

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

A Multi-Objective Optimization Problem Solving Method Based on Improved Golden Jackal Optimization Algorithm and Its Application

Biomimetics
The traditional golden jackal optimization algorithm (GJO) has slow convergence speed, insufficient accuracy, and weakened optimization ability in the process of finding the optimal solution.
Shijie Jiang, Yinggao Yue, Changzu Chen, Yaodan Chen, Li Cao   +4 more
doaj   +1 more source

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Typical path components in tent map inverse limits [PDF]

, 2020
de Carvalho, André, Boyland, Philip, Hall, Toby   +2 more
core   +1 more source

The Tent Chaotic Mapping: Analysis for Generation of Binary Codes for Better Performance by Using MATLAB [PDF]

, 2011
In this paper, the Tent map is analyzed as a source of pseudorandom bits. To evaluate the performance ofthe proposed pseudorandom bit generator, different issues were considered, such as the period length, thediscriminator value and the merit factor. The
Mohan, G.S.S.S.S.V.K., NagaVamsi, Annepu .Venkata, Patnaik, Pradeep Kumar   +2 more
core   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Three-Dimensional UAV Path Planning Based on Multi-Strategy Integrated Artificial Protozoa Optimizer

Biomimetics
Three-dimensional UAV path planning is crucial in practical applications. However, existing metaheuristic algorithms often suffer from slow convergence and susceptibility to becoming trapped in local optima.
Qingbin Sun, Xitai Na, Zhihui Feng, Shiji Hai, Jinshuo Shi   +4 more
doaj   +1 more source