Veterinary Medicine International, 2022 There are scarce in vitro studies indicating the basic mechanisms of why platelet-rich plasma (PRP) is useful in the clinical management of dogs with naturally occurring OA. Methods.
Miller Gallego +2 more
doaj +2 more sources
Model of Liver Fibrosis Induction by Thioacetamide in Rats for Regenerative Therapy Studies
Analytical Cellular Pathology, 2022 Hepatic fibrosis is caused by chronic injury due to toxic, infectious, or metabolic causes, and it may progress to cirrhosis and hepatocellular carcinoma.
Nathaly Enciso +7 more
doaj +2 more sources
Topology-Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates. [PDF]
SmallElectrostatic topology is shown to program phase separation and internal organization in thermoresponsive intrinsically disordered protein polymer (IDPP) condensates. By comparing oppositely charged IDPPs with a covalent diblock, chain connectivity is revealed to control charge compensation, dense‐phase micropolarity, miscibility, and apparent acid ...
Fernández-Fernández J +6 more
europepmc +2 more sources
Bone Marrow Mononuclear Cells and Plasma Gel as Combination Treatment for Hard-to-Heal Wounds [PDF]
LifeHard-to-heal wounds pose a significant challenge in clinical practice due to the fact that the conventional treatments used are not always effective. For this reason, it is necessary to design alternatives to achieve an adequate resolution.
Silvia Perez-Lopez +8 more
doaj +2 more sources
Veterinary Medicine International, 2022 There is scarce information about bovine platelet-rich plasma/platelet-rich gel (PRP/PRG) and related hemocomponents (HCs), such as platelet lysates (PLs), including growth factor (GF) and cytokine concentrations, and how the stability of these ...
Jorge U. Carmona +2 more
doaj +2 more sources
TERAPIA REGENERATIVA EN NEONATOLOGÍA
Revista Médica Clínica Las Condes, 2016 La terapia regenerativa con células madre o mesenquimales, aparece como una interesante posibilidad en neonatología, principalmente en aquellas enfermedades crónicas, en las cuales la patogenia involucra mecanismos inflamatorios persistentes, con los ...
Dr. Hernán Villalón +2 more
exaly +3 more sources
Enzymatic Poly(gallic acid)-grafted L-Histidine Reduces Cell Inflammation and Oxidative Stress: In Silico and In Vitro Studies. [PDF]
Chem BiodiversMicrowave‐assisted grafting yields a PGAL–His conjugate with enhanced binding through electrostatic and hydrogen‐bond interactions. The material modulates THP‐1 macrophage response, reducing ROS production, pro‐inflammatory cytokines (IL‐6, IL‐1β, TNF‐α), and cell adhesion.
Hernández-Valencia CG +10 more
europepmc +2 more sources
Biohybrid Vascular Graft Made of Textile-Reinforced Elastin-Like Recombinamers and Its Preservation via Drying Processes. [PDF]
Adv Healthc MaterClinical translation of biohybrid medical implants requires the previous implementation of drying schemes that can facilitate their sterilization and storage. This study addresses that critical aspect and elucidates the impact of drying on biohybrid vascular grafts, highlighting the need for implant‐specific drying strategies to ensure safety ...
Andre DP +5 more
europepmc +2 more sources
Prolonged Release of IL-10 From Enzyme-Mediated Poly-l-(Tyrosine-co-Phenylalanine) Nanocrystals Enhances Stability and Modulates Inflammatory Responses. [PDF]
BiopolymersSchematic representation of enzyme‐mediated peptide nanocrystal formation and IL‐10 encapsulation, providing stabilized and sustained cytokine delivery that modulates macrophage phenotype and reduces inflammatory responses. ABSTRACT Protease‐catalyzed synthesis of a peptide composed of l‐tyrosine and l‐phenylalanine (2.2:1 M ratio) was achieved in a ...
Landa-Tencle F +11 more
europepmc +2 more sources
Phenotypic Differences in Inflammatory, Metabolic, and Biochemical Biomarkers in Dogs with Osteoarthritis According to Body Condition and Sex [PDF]
AnimalsOsteoarthritis (OA) in dogs is increasingly recognized as a condition with systemic inflammatory and metabolic components, potentially influenced by body condition and sex.
Liceth Agudelo-Giraldo +2 more
doaj +2 more sources