Results 1 to 10 of about 767,779 (167)

Medicina Regenerativa em dor crónica: entre o potencial transformador e os desafios da implementação

Revista Dor
A Medicina Regenerativa tem-se destacado como abordagem promissora no tratamento da Dor Crónica, permitindo não só o alívio dos sintomas, mas também a possibilidade de modificar o curso natural da doença.
Nuno Ferreira-Silva, Tomás Ribeiro-da-Silva, Rita Ribas   +2 more
exaly   +4 more sources

Qualidade dos produtos de terapias avançadas: requisitos de células extensamente manipuladas usadas em terapias celulares e em bioengenharia

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introdução: O preparo de produtos para terapias avançadas inclui, frequentemente, a manipulação extensa de células primárias in vitro, o que pode acarretar em alterações da população celular final.
Rosana Bizon Carias, Karla Menezes, Esther Rieko Takamori, Radovan Borojevic   +3 more
doaj   +7 more sources

Model of Liver Fibrosis Induction by Thioacetamide in Rats for Regenerative Therapy Studies

Analytical Cellular Pathology, 2022
Hepatic fibrosis is caused by chronic injury due to toxic, infectious, or metabolic causes, and it may progress to cirrhosis and hepatocellular carcinoma.
Nathaly Enciso, José Amiel, Fredy Fabián-Domínguez, Jhon Pando, Nancy Rojas, Carlos Cisneros-Huamaní, Ernesto Nava, Javier Enciso   +7 more
doaj   +1 more source

Harmful R-loops are prevented via different cell cycle-specific mechanisms

Nature Communications, 2021
Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a ...
Marta San Martin-Alonso, María E. Soler-Oliva, María García-Rubio, Tatiana García-Muse, Andrés Aguilera   +4 more
doaj   +1 more source

Systemically administered allogeneic mesenchymal stem cells do not aggravate the progression of precancerous lesions: a new biosafety insight

Stem Cell Research & Therapy, 2018
Background Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal cells currently tested for multiple therapeutic purposes. Their potential to home into tumors, to secrete trophic/vasculogenic factors, and to suppress immune response raises ...
Flavia Bruna, Anita Plaza, Martha Arango, Iris Espinoza, Paulette Conget   +4 more
doaj   +1 more source

Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review

Stem Cells International, 2021
Mesenchymal stem cells (MSC) are adult multi-potent cells that can be isolated from many types of tissues including adipose tissue, bone marrow, and umbilical cord.
Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion   +5 more
doaj   +1 more source

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

Cell Death and Disease, 2022
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival.
Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas, Carmen Palacios   +5 more
doaj   +1 more source

Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles

Drug Delivery, 2020
Throughout the last decade, extracellular vesicles (EVs) have become increasingly popular in several areas of regenerative medicine. Recently, Apis mellifera royal jelly EVs (RJ EVs) were shown to display favorable wound healing properties such as ...
Orlando J. Ramírez, Simón Alvarez, Pamina Contreras-Kallens, Nelson P. Barrera, Sebastian Aguayo, Christina M. A. P. Schuh   +5 more
doaj   +1 more source

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Scientific Reports, 2021
Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly ...
Sandra Torres Galván, María Flores-López, Pablo Romero-Sanchiz, Nerea Requena-Ocaña, Oscar Porras-Perales, Raquel Nogueira-Arjona, Fermín Mayoral, Pedro Araos, Antonia Serrano, Roberto Muga, Francisco Javier Pavón, Nuria García-Marchena, Fernando Rodríguez de Fonseca   +12 more
doaj   +1 more source

Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency

Stem Cell Research, 2016
Little is known about the functions of downstream regulatory element antagonist modulator (DREAM) in embryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
A. Fontán-Lozano, V. Capilla-Gonzalez, Y. Aguilera, N. Mellado, A.M. Carrión, B. Soria, A. Hmadcha   +6 more
doaj   +1 more source