Results 21 to 30 of about 782,998 (207)

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

Cell Death and Disease, 2022
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival.
Rosario Yerbes, Rocío Mora-Molina, F. Javier Fernández-Farrán, Laura Hiraldo, Abelardo López-Rivas, Carmen Palacios   +5 more
doaj   +1 more source

Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles

Drug Delivery, 2020
Throughout the last decade, extracellular vesicles (EVs) have become increasingly popular in several areas of regenerative medicine. Recently, Apis mellifera royal jelly EVs (RJ EVs) were shown to display favorable wound healing properties such as ...
Orlando J. Ramírez, Simón Alvarez, Pamina Contreras-Kallens, Nelson P. Barrera, Sebastian Aguayo, Christina M. A. P. Schuh   +5 more
doaj   +1 more source

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

Scientific Reports, 2021
Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly ...
Sandra Torres Galván, María Flores-López, Pablo Romero-Sanchiz, Nerea Requena-Ocaña, Oscar Porras-Perales, Raquel Nogueira-Arjona, Fermín Mayoral, Pedro Araos, Antonia Serrano, Roberto Muga, Francisco Javier Pavón, Nuria García-Marchena, Fernando Rodríguez de Fonseca   +12 more
doaj   +1 more source

Avances en medicina regenerativa [PDF]

, 2017
Además de los autotrasplantes de médula ósea para tratamiento de leucemias y de piel para regeneración de quemaduras, existen nuevas técnicas y avances clínicos muy recientes en medicina regenerativa.
Coll Morales, Julio
core   +1 more source

Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency

Stem Cell Research, 2016
Little is known about the functions of downstream regulatory element antagonist modulator (DREAM) in embryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
A. Fontán-Lozano, V. Capilla-Gonzalez, Y. Aguilera, N. Mellado, A.M. Carrión, B. Soria, A. Hmadcha   +6 more
doaj   +1 more source

Técnicas del futuro: ingeniería de tejidos y uso de células madre en medicina reproductiva

Revista Médica Clínica Las Condes, 2010
Últimamente ha cobrado gran interés en la comunidad médica y científica, el avance experimentado por la medicina regenerativa, la ingeniería de tejidos y el uso de terapias celulares en base a células autólogas maduras, como también el uso de células ...
V. Cecilia Fabres, Dra.
doaj   +1 more source

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Nature Communications, 2020
The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies.
Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma   +10 more
doaj   +1 more source

Bioinductive collagen implants facilitate tendon regeneration in rotator cuff tears

Journal of Experimental Orthopaedics, 2022
Purpose To evaluate the clinical outcomes, MRI imaging and histological characteristics of biopsy samples of the tendon from patients in whom rotator cuff repair was previously performed with a bioinductive type I bovine collagen implants.
Jorge Alberto Camacho‐Chacon, Jorge Cuenca‐Espierrez, Victor Roda‐Rojo, Adrian Martin‐Martinez, Jose Manuel Calderon‐Meza, Ramiro Alvarez‐Alegret, Carlos Martin‐Hernandez   +6 more
doaj   +1 more source

DNA-RNA hybrids at DSBs interfere with repair by homologous recombination

eLife, 2021
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome integrity. The readout of DSB repair may depend on whether DSBs occur at transcribed versus non-transcribed regions.
Pedro Ortega, José Antonio Mérida-Cerro, Ana G Rondón, Belén Gómez-González, Andrés Aguilera   +4 more
doaj   +1 more source

Temporomandibular joint regeneration: proposal of a novel treatment for condylar resorption after orthognathic surgery using transplantation of autologous nasal septum chondrocytes, and the first human case report

Stem Cell Research & Therapy, 2018
Background Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity.
Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cláudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debora Regina Daga, Paulo Roberto Slud Brofman, Radovan Borojevic   +11 more
doaj   +1 more source