Results 11 to 20 of about 1,649 (176)

Enzymatic Poly(gallic acid)-grafted L-Histidine Reduces Cell Inflammation and Oxidative Stress: In Silico and In Vitro Studies. [PDF]

open access: yesChem Biodivers
Microwave‐assisted grafting yields a PGAL–His conjugate with enhanced binding through electrostatic and hydrogen‐bond interactions. The material modulates THP‐1 macrophage response, reducing ROS production, pro‐inflammatory cytokines (IL‐6, IL‐1β, TNF‐α), and cell adhesion.
Hernández-Valencia CG   +10 more
europepmc   +2 more sources

Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review

open access: yesStem Cells International, 2021
Mesenchymal stem cells (MSC) are adult multi-potent cells that can be isolated from many types of tissues including adipose tissue, bone marrow, and umbilical cord.
Sarah Ezquerra   +5 more
doaj   +1 more source

Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells

open access: yesCell Death and Disease, 2022
Oncogenic transformation leads to changes in glutamine metabolism that make transformed cells highly dependent on glutamine for anabolic growth and survival.
Rosario Yerbes   +5 more
doaj   +1 more source

Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles

open access: yesDrug Delivery, 2020
Throughout the last decade, extracellular vesicles (EVs) have become increasingly popular in several areas of regenerative medicine. Recently, Apis mellifera royal jelly EVs (RJ EVs) were shown to display favorable wound healing properties such as ...
Orlando J. Ramírez   +5 more
doaj   +1 more source

Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder

open access: yesScientific Reports, 2021
Granulocyte colony–stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly ...
Sandra Torres Galván   +12 more
doaj   +1 more source

Potencialidad Celular Evolutiva y Medicina Regenerativa [PDF]

open access: yesInternational Journal of Morphology, 2012
Las celulas derivadas del embrioblasto o macizo celular interno (MCI) del blastocisto corresponden a las celulas madres embrionarias, ellas son pluripotentes, debido a que tienen la capacidad de generar todas las estirpes celulares y al resto, se les conoce como celulas madres adultas porque tienen un potencial de diferenciacion mucho mas restringido ...
Rojas, Mariana, Meruane, Manuel
openaire   +2 more sources

Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency

open access: yesStem Cell Research, 2016
Little is known about the functions of downstream regulatory element antagonist modulator (DREAM) in embryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
A. Fontán-Lozano   +6 more
doaj   +1 more source

Técnicas del futuro: ingeniería de tejidos y uso de células madre en medicina reproductiva

open access: yesRevista Médica Clínica Las Condes, 2010
Últimamente ha cobrado gran interés en la comunidad médica y científica, el avance experimentado por la medicina regenerativa, la ingeniería de tejidos y el uso de terapias celulares en base a células autólogas maduras, como también el uso de células ...
V. Cecilia Fabres, Dra.
doaj   +1 more source

Biohybrid Vascular Graft Made of Textile-Reinforced Elastin-Like Recombinamers and Its Preservation via Drying Processes. [PDF]

open access: yesAdv Healthc Mater
Clinical translation of biohybrid medical implants requires the previous implementation of drying schemes that can facilitate their sterilization and storage. This study addresses that critical aspect and elucidates the impact of drying on biohybrid vascular grafts, highlighting the need for implant‐specific drying strategies to ensure safety ...
Andre DP   +5 more
europepmc   +2 more sources

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

open access: yesNature Communications, 2020
The ATM kinase is a key regulator of the DNA damage response to double-strand breaks (DSBs) and its homozygous loss in patients predisposes to lymphoid malignancies.
Alejandro Álvarez-Quilón   +10 more
doaj   +1 more source

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