LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
The development of biomedical sciences has been strengthened with the technology in other fields ; such was the case with the invention of photography, the latter represented a breakthrough in scientific objectivity required by the registration of the ...
Oliva López Sánchez
doaj +1 more source
Ethylenebisdithiocarbamates and ethylenethiourea: possible human health hazards. [PDF]
Humans are exposed to ethylenebisdithiocarbamates (EBDCs) from environmental sources. Exposure to EBDCs is chronic for workers in a variety of industries, where EBDCs are used for their properties as slimicides, vulcanization accelerators, antioxidants ...
Bindoula, G, Hoffman, JR, Houeto, P
core +2 more sources
The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang +16 more
wiley +1 more source
Altering HIF-1α through 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure affects coronary vessel development. [PDF]
Differential tissue hypoxia drives normal cardiogenic events including coronary vessel development. This requirement renders cardiogenic processes potentially susceptible to teratogens that activate a transcriptional pathway that intersects with the ...
Karunamuni, Ganga +6 more
core +2 more sources
ABSTRACT Purpose Pharmacotherapy during pregnancy should be approached with caution due to the potential risk of adverse effects, including birth defects, in the fetus. Appropriate post‐marketing surveillance and perinatal pharmacoepidemiology are essential to ensure the safety of pharmacotherapy during pregnancy.
Shiro Hatakeyama +8 more
wiley +1 more source
El encuentro de un monstruo y una histérica. Una imagen para México en los finales del siglo XIX
In the last decades of the XIX century grew the interest of Mexican physicians for new topics. With avidly, they wanted to know everything that was taking place in Europe.
Frida Gorbach
doaj +1 more source
Postnatal choline supplementation improves sleep in a rat model of developmental alcohol exposure
This study is the first to examine whether postnatal treatment with choline, an essential nutrient, alters sleep in rats exposed to prenatal ethanol. Results illustrate that both developmental alcohol exposure and early nutrition can have long‐lasting and sex‐dependent effects on sleep in adolescents.
Jaclyn B. Hanson +3 more
wiley +1 more source
EUROPEAN TERATOLOGY INFORMATION SERVICE: EXPERIENCE, PROBLEMS AND PERSPECTIVES
Congenital malformations are still the important medical and social issue. They take the second place among the reasons for the infant mortality and cause up to 18,3% of disablement cases among the children. Exogenous factors, effecting the growing fetus,
A.V. Ostrovskaya +2 more
doaj +2 more sources
Teratogenic effects of gabapentin on the skeletal system of Balb/C mice fetuses [PDF]
Objectives: To evaluate the effects of gabapentin )GBP( administration on mice fetuses. Methods: This study was carried out in Birjand University of Medical Sciences during 2008.
Afshar, M. +4 more
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