Intensive Chemotherapy With or Without Midostaurin in Adults ≥ 60 Years Old With FLT3-Mutated AML: A FILO-DATAML-PETHEMA Real-World Study. [PDF]
ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Aspas Requena G +31 more
europepmc +2 more sources
Discriminative features for Alzheimer disease based on peripheral blood deep‐immunophenotyping [PDF]
Abstract Background Immunity is a key driving factor in pathogenesis and progression of Alzheimer's disease. Here we examine the peripheral changes in both innate and adaptive immunity in AD and healthy subjects between 50 and 80 years old by immunophenotyping and systems immunology.
Feng Y +8 more
europepmc +2 more sources
O arquétipo da mãe na ficção de Teresa Veiga: o caso de “As Parcas”
. O arquétipo da mãe, detetado em vários mitos de origem não apenas indo-europeia, é uma constante na literatura de todos os tempos. A questão da maternidade é também uma das matrizes do imaginário de Teresa Veiga, cuja presença pode ser rastreada desde
Silvie Špánková
exaly +7 more sources
A systems immunology analysis of Alzheimer's disease reveals an age- and environmental exposure-independent disturbance in B cell maturation. [PDF]
Abstract INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinical investigation suggests a neuroimmunological component to disease, with links to the peripheral immune system.
Humblet-Baron S +8 more
europepmc +2 more sources
A phase 2, multicenter, clinical trial of CPX-351 in older patients with secondary or high-risk acute myeloid leukemia: PETHEMA-LAMVYX. [PDF]
Abstract Background LAMVYX was a multicenter, single‐arm, phase 2 trial designed to validate the safety and efficacy of CPX‐351 in patients aged 60–75 years with newly diagnosed, secondary acute myeloid leukemia and to generate evidence on key issues not addressed in the preceding regulatory pivotal trial. Methods The primary end point of the study was
Rodríguez-Arbolí E +23 more
europepmc +2 more sources
Abdominal splenosis mimicking peritoneal carcinomatosis of ovarian cancer [PDF]
We present the clinical case of a 53-year-old woman referred for suspicion of recurrence of a mesonephric-like adenocarcinoma of the ovary. Abdominal and pelvic CT revealed multiple round/oval solid nodules with similar density scattered throughout the ...
Filipe Barros Alves, MD +5 more
doaj +2 more sources
DNA Barcode library of the endemic-rich avifauna of the oceanic islands of the Gulf of Guinea [PDF]
The BioSTP: DNA Barcoding of endemic birds from oceanic islands of the Gulf of Guinea dataset contains records of 155 bird specimens belonging to 56 species in 23 families, representing over 80% of the diversity of the breeding landbird community.
Martim Melo +13 more
doaj +4 more sources
Cross-National Analysis of Consumer Preferences for Organic Food in Portugal, Spain, and Greece: Socio-Demographic Drivers and Attribute Importance [PDF]
Consumer demand for organic products has grown substantially in Southern Europe, driven by health, environmental, and ethical concerns. Understanding cross-country differences in attribute preferences and sociodemographic influences is critical to inform
Teresa Madureira +7 more
doaj +2 more sources
Predominance of Trichophyton soudanense as Agent of Dermatophytoses in Cape Verdean School-Age Children [PDF]
Dermatophytoses are infectious skin diseases of public health importance because of their transmissibility and high prevalence, especially among children.
Edmilson Emanuel Monteiro Correia +4 more
doaj +2 more sources
Machine Learning Techniques Associated With Infrared Thermography to Optimize the Diagnosis of Bovine Subclinical Mastitis. [PDF]
Bovine subclinical mastitis (SCM) is the costliest disease for the dairy industry. Technologies aimed at the early diagnosis of this condition, such as infrared thermography (IRT), can be used to generate large amounts of data that provide valuable information when analyzed using learning techniques.
Santana RCM +10 more
europepmc +2 more sources

