A systems immunology analysis of Alzheimer's disease reveals an age- and environmental exposure-independent disturbance in B cell maturation. [PDF]
Abstract INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinical investigation suggests a neuroimmunological component to disease, with links to the peripheral immune system.
Humblet-Baron S +8 more
europepmc +2 more sources
A phase 2, multicenter, clinical trial of CPX-351 in older patients with secondary or high-risk acute myeloid leukemia: PETHEMA-LAMVYX. [PDF]
Abstract Background LAMVYX was a multicenter, single‐arm, phase 2 trial designed to validate the safety and efficacy of CPX‐351 in patients aged 60–75 years with newly diagnosed, secondary acute myeloid leukemia and to generate evidence on key issues not addressed in the preceding regulatory pivotal trial. Methods The primary end point of the study was
Rodríguez-Arbolí E +23 more
europepmc +2 more sources
Invar, also known as FeNi36, is a material of great interest due to its unique properties, which makes it an excellent alternative for sectors such as tooling in aeronautics and aerospace. Its manufacture by means of wire arc additive manufacturing (WAAM)
F. Veiga +3 more
semanticscholar +1 more source
Discriminative features for Alzheimer disease based on peripheral blood deep‐immunophenotyping [PDF]
Abstract Background Immunity is a key driving factor in pathogenesis and progression of Alzheimer's disease. Here we examine the peripheral changes in both innate and adaptive immunity in AD and healthy subjects between 50 and 80 years old by immunophenotyping and systems immunology.
Feng Y +8 more
europepmc +2 more sources
The Organic Food Choice Pattern: Are Organic Consumers Becoming More Alike?
There is no doubt that the search for organic products is already more than a trend; it is an indisputable reality. More and more people are opting for a healthier lifestyle that starts with food, which has awakened a growing interest in understanding ...
Fernando Nunes +2 more
doaj +1 more source
Fibromyalgia (FM) is a chronic pain syndrome with a strong impact on quality of life (QoL). Treatment of this condition remains a challenge, due to the scarce evidence for the effectiveness of the therapeutic approaches available.
N. Samartin-Veiga +4 more
semanticscholar +1 more source
Machine Learning Techniques Associated With Infrared Thermography to Optimize the Diagnosis of Bovine Subclinical Mastitis. [PDF]
Bovine subclinical mastitis (SCM) is the costliest disease for the dairy industry. Technologies aimed at the early diagnosis of this condition, such as infrared thermography (IRT), can be used to generate large amounts of data that provide valuable information when analyzed using learning techniques.
Santana RCM +10 more
europepmc +2 more sources
Indications for Digital Monitoring of Patients With Multiple Nevi: Recommendations from the International Dermoscopy Society. [PDF]
Introduction In patients with multiple nevi, sequential imaging using total body skin photography (TBSP) coupled with digital dermoscopy (DD) documentation reduces unnecessary excisions and improves the early detection of melanoma.
Russo T +28 more
europepmc +2 more sources
Histological alterations and oxidative stress in adult zebrafish muscle after aluminium exposure.
Aluminium (Al) is among the most abundant metals in nature, and its presence in the environment is further increasing by anthropogenic activities. In water bodies, the Al concentrations ranged between 0.001-50mg/L, raising concerns about the health of ...
I. Ferrandino +5 more
semanticscholar +1 more source
História da Educação e Covid-19:
Que potenciais conhecimentos ou dispositivos decorrem da pesquisa em História da Educação para adensar compreensões e dimensionar os impactos da Pandemia COVID-19 na Educação Escolar?
Tony Honorato, Ana Clara Bortoleto Nery
doaj +1 more source

