Results 61 to 70 of about 17,280 (228)

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 11-23, January 2026.
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

Teriparatide treatment in severe osteoporosis – a controlled 10-year follow-up study

BMC Musculoskeletal Disorders, 2022
Background Teriparatide was the first anabolic agent recommended for the treatment of osteoporosis. Long-term real-world, controlled studies are not available.
Georgios Kontogeorgos, Emily Krantz, Penelope Trimpou, Christine M. Laine, Kerstin Landin-Wilhelmsen   +4 more
doaj   +1 more source

Bisphosphonate-induced periprosthetic fracture: a cause of painful total hip arthroplasty [PDF]

, 2014
Background. Cases have been reported in the literature of periprosthetic fractures associated with the use of bisphosphonates occurring in the long term following a Total Hip Replacement (THR).
Bhattacharyya, Rahul, O’Neill, Gavin, Periasamy, Kumar, Spence, Stephanie   +3 more
core   +4 more sources

First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product

Pharmaceutics
Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free alternatives under biosimilar or hybrid regulatory application.
Jimena Fernández-Carneado, Mariona Vallès-Miret, Sílvia Arrastia-Casado, Ana Almazán-Moga, Maria J. Macias, Pau Martin-Malpartida, Marta Vilaseca, Mireia Díaz-Lobo, Mayte Vazquez, Rosa M. Sanahuja, Gemma Gambús, Berta Ponsati   +11 more
doaj   +1 more source

PPAR gamma/mTOR signalling: striking the right balance in cartilage homeostasis [PDF]

, 2015
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work ...
Afif, Betz, Boileau, Caramés, Chen, Damyanovich, Francesco Dell'Accio, Glasson, Jacinto, Joanna Sherwood, Johnson, Kim, Laplante, Miller, Reginster, Saito, Sampson, Sarbassov, Sherwood, Vasheghani, Vasheghani, Yang, Yin, Zhang   +23 more
core   +2 more sources

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Effects of teriparatide and bisphosphonate on spinal fusion procedure: A systematic review and network meta-analysis.

PLoS ONE, 2020
BackgroundGiving patients anti-osteoporotic agents peri-operatively is a well-accepted strategy to increase fusion rate and prevent complications. The purpose of this study was to investigate effectiveness of teriparatide and bisphosphonate on fusion ...
Shih-Hao Cheng, Yi-Jie Kuo, Chiehfeng Chen, Yi-No Kang   +3 more
doaj   +1 more source

Beware of bone pain with bisphosphonates [PDF]

, 2019
A 71-year-old woman who had been taking ibandronate for 10 years presented to an Endocrinology Department with persistent mid-thigh pain. Pelvic X-ray showed bilateral femoral cortical expansion, indicating impending atypical femoral fractures (AFFs ...
Fraser, William, Mailoo, Venthan Jeyarantan, Srinivas, Vidya, Turner, Jeremy   +3 more
core   +1 more source

Role of Branched‐Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Osteosarcopenia, characterised by concurrent bone loss and muscle atrophy, presents a significant challenge in aging populations, particularly in postmenopausal women. The current therapeutic options potentially treat bone and muscle loss independently, highlighting the importance of an integrated approach.
Geum‐Hwa Lee, Hwa‐Young Lee, Young‐Jae Lim, Se‐Woong Ko, Han‐Jung Chae, Sun‐Jung Yoon   +5 more
wiley   +1 more source

Therapeutic Approaches for Enhancing Spinal Fusion in Low Back Pain: A Review With a Focus on the Elderly

JOR SPINE, Volume 8, Issue 4, December 2025.
The review summarizes the current clinical problems of non‐spinal fusions in orthopaedics. I refers to selected biological examples of how ossification can be better achieved in elderly patients. ABSTRACT Background Low back pain (LBP) is a prevalent cause of disability worldwide, particularly among the elderly, with degenerative spinal conditions ...
Shuimu Chen, Zhen Li, Sebastian F. Bigdon, Sonja Häckel, Christoph E. Albers, Benjamin Gantenbein   +5 more
wiley   +1 more source