Results 191 to 200 of about 17,107,280 (257)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Comparison of Outcomes From Intermittent Hemodialysis and Continuous Renal Replacement Therapy With Systemic or Regional Anticoagulation in 128 Patients in a Polish Intensive Care Unit. [PDF]

Med Sci Monit
Wolska J, Onichimowski D, Samiec M, Podlińska I, Radkowski P.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries.

BMJ
Duru O, Santoni G, Holmberg D, Birgisson H, Kauppila JH, von Euler-Chelpin M, Ness-Jensen E, Lagergren J.   +7 more
europepmc   +1 more source

How effective are international deployments in strengthening low- and middle-income countries (LMICs) to respond to outbreaks in the long term? [PDF]

BMJ Glob Health
Nzegwu F, Haque F, Clery E, Kamara N, Nkunzimana E, Tegegne MA, Newman EN, Bigirimana R.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Association of Pre-Fontan Hemodynamics With Long-Term Outcomes After Fontan Palliation: A Study From the Pediatric Cardiac Care Consortium. [PDF]

Circulation
Suthar D, Yang Y, Beshish AG, Knight J, Song X, Thomas A, Hao H, Shaw FR, Jenkins K, Jacobs JP, Oster ME, Alonso A, Huang Y, Raghuveer G, Hiremath G, Marino B, Wright L, Deshpande SR, John AS, Gaitonde MM, Alsoufi B, Overman DM, Canter C, St Louis J, Devanagondi R, McHugh KE, Kochilas L.   +26 more
europepmc   +1 more source