Results 251 to 260 of about 17,180,005 (307)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Increased semaphorin, neuropilin, and plexin expression plays a role in recovery after traumatic brain injury. [PDF]

Metab Brain Dis
Okan A, Yılmaz Şükranlı Z, Bor TB, Berkyürek Aİ, Taheri S, Doğanyiğit Z.   +5 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Insights into the gaps and requirements of long-term care in Iran: a qualitative content analysis approach. [PDF]

BMC Geriatr
Ghasemyani S, Mobasseri K, Jafari M, Zarngh RK, Aboulhallaj M.   +4 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Longitudinal Associations Between Work-Related Factors and the Need for Recovery of Long-Term Care Workers. [PDF]

Nurs Health Sci
Dams LJJ, Heijkants CH, Boot CRL.
europepmc   +1 more source

Intraoperative Visual Evoked Potential Monitoring in Endoscopic Endonasal Surgery for Nonpituitary Adenoma Suprasellar Tumors. [PDF]

J Clin Neurol
Kwon YN, Lee HR, Lee MJ, Kim YU, Kim SW, Shin HY, Kim SM, Moon JH, Chang JH, Kim EH.   +9 more
europepmc   +1 more source

Surgical Treatment of End-Stage Hallux Rigidus Using a Total All-Ceramic Endoprosthesis: A Short-Term case series and literature review. [PDF]

Orthop Rev (Pavia)
Nurakhmetov A, Petrov A, Nikolaenko A, Tazhin K.   +3 more
europepmc   +1 more source

Making clinical guidelines work for people with multiple long term conditions: analysis and recommendations from review of single condition guidelines. [PDF]

BMJ Med
Pretorius S, Bartle V, Bellass S, Blackburn ER, Bold H, Cooper R, Cordell H, Evison F, Holding R, Howe N, Lam E, Marshall T, Matthews F, Missier P, Pearson ER, Plummer C, Richards G, Robinson SM, Sapey E, Scharf T, Singer M, Suklan J, Walker P, Wason J, Sayer AA, Witham MD.   +25 more
europepmc   +1 more source