Results 71 to 80 of about 289,495 (300)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Localized Spillovers and Knowledge Flows: How Does Proximity Influence the Performance of Plants? [PDF]

By means of a unique longitudinal database with information on all plants and employees in the Swedish economy, this paper analyzes how geographical proximity influences the impact of spillovers and knowledge flows on the productivity growth of plants ...
Rikard Eriksson
core  

Book of Abstracts. A global strategy for local problems or a local strategy for global problems. Proximity Planning International Congress.

The search for a greater “proximity” in the project of contemporary cities is the current challenge facing our society. Following the onset of the Covid-19 pandemic in 2020, both national and international debates have pivoted towards transitioning from ...
Borini, Martina
core   +1 more source

An Information Retrieval Model Using the Fuzzy Proximity Degree of Term Occurences

, 2005
International audienceBased on the idea that the closer the query terms in a document are, the more relevant this document is, we propose a mathematical model of information retrieval based on a fuzzy proximity degree of term occurences.
Annabelle Mercier, Beigbeder, Michel, Michel Beigbeder, Mercier, Annabelle   +3 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Echoes of our Touch: the nexus between humanity and the earth in Véronique Tadjo’s ‘In the Company of Men’

Cogent Arts & Humanities
This article interrogates the destructive socio-ecological nexus in Véronique Tadjo’s In the Company of Men (2021) through a synthesis of Cajetan Iheka’s framework of ‘proximity’ and Rob Nixon’s concept of ‘slow violence’.
Yohana Michael Lukinga
doaj   +1 more source

Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis

Environmental Health, 2017
Background Epidemiologic studies have raised the possibility that some pesticide compounds induce the neurodegenerative disease amyotrophic lateral sclerosis (ALS), though the available evidence is not entirely consistent.
Marco Vinceti, Tommaso Filippini, Federica Violi, Kenneth J. Rothman, Sofia Costanzini, Carlotta Malagoli, Lauren A. Wise, Anna Odone, Carlo Signorelli, Laura Iacuzio, Elisa Arcolin, Jessica Mandrioli, Nicola Fini, Francesco Patti, Salvatore Lo Fermo, Vladimiro Pietrini, Sergio Teggi, Grazia Ghermandi, Renato Scillieri, Caterina Ledda, Cristina Mauceri, Salvatore Sciacca, Maria Fiore, Margherita Ferrante   +23 more
doaj   +1 more source

Replication Data for: Electoral Proximity and Issue-Specific Responsiveness

, 2023
Do elections increase responsiveness of legislators to their constituents? I utilize a natural experiment in four state legislatures -- Arkansas, Florida, Illinois, and Texas -- where term length was randomly assigned.
Pomirchy, Michael
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source