Results 61 to 70 of about 289,495 (300)

Similarity Ratio Based Adaptive Mahalanobis Distance Algorithm to Generate SAR Superpixels

Canadian Journal of Remote Sensing, 2017
Superpixel algorithms are aimed to partition an image into multiple similar sized segments based on similarity and proximity of pixels. In the heterogeneous regions, the boundaries of the objects should adhere well to the superpixels, and in the ...
Emre Akyilmaz, Ugur Murat Leloglu
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dopamine Modulation of Reunion Behavior in Short and Long Term Marmoset Pairs

Frontiers in Ecology and Evolution, 2018
One major neurobiological substrate regulating social processes is dopamine (DA). DA is implicated in social behavior in species as diverse as fish and birds, and has an established role in regulating relationships between mates in socially monogamous ...
Sarah B. Carp, Jack H. Taylor, Stephanie L. Womack, Stephanie L. Womack, Jeffrey A. French, Jeffrey A. French   +5 more
doaj   +1 more source

Constructing proximity: relating to readers in popular and professional science [PDF]

, 2010
The view of academic discourse as a rhetorical activity involving interactions between writers and readers is now central to most perspectives on EAP, but these interactions are conducted differently in different disciplinary and generic contexts.
Hyland, Ken, Hyland, K
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Proximal humerus chondrosarcoma. Long-term clinical and oncological outcomes

Revista Española de Cirugía Ortopédica y Traumatología (English Edition), 2019
The proximal humerus is a common site for primary bone sarcomas, of which chondrosarcoma represents 15%. There are few reports about this select group of tumours. We set out to analyse a group of patients with proximal humerus chondrosarcoma treated with surgery and to assess their long term surgical and oncological outcomes.A retrospective review was ...
J I, Albergo, G L, Farfalli Luis, M A, Ayerza, D L, Muscolo, L A, Aponte-Tinao   +4 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Geography of Scientific Knowledge: A Proximity Approach [PDF]

The geography of scientific knowledge is defined as the replication process of locally produced knowledge claims. Proximity in social, cognitive, and physical dimensions promotes the sharing of tacit knowledge.
Koen Frenken
core  

The long-term consequences of short-term responses to disturbance: Experiences from whalewatching impact assessment

, 2007
Studies often use behavioral responses to detect the impact of given disturbances on animals. However, the observation of these short-term responses can often lead to contradicting results.
Bejder, Lars, Lusseau, D., Lusseau, David, Bejder, L.   +3 more
core   +1 more source