Results 111 to 120 of about 8,969 (257)

Adaptive composite loss for volumetric whole heart segmentation

Scientific Reports
Accurate segmentation in medical imaging requires loss functions that capture both regional overlap and boundary alignment. This study evaluates composite losses combining binary cross-entropy (BCE) and a boundary-based term under fixed and adaptive ...
Krittanat Sutassananon, Worapan Kusakunniran, Mehmet Orgun, Thanongchai Siriapisith   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Grammatical Dependency-Based Relations for Term Weighting in Text Classification

, 2011
Term frequency and term co-occurrence are currently used to estimate term weightings in a document. However these methods do not employ relations based on grammatical dependency among terms to measure dependency between word features.
Sharma, Dharmendra; id_orcid, Dharmendra Sharma, Ma, Wanli, Dat Huynh, Wanli Ma, Dat Tran, Tran, Dat; id_orcid, Hyunh, Dat   +7 more
core   +1 more source

Effects Of Age And Gender On Short-Term Weight Loss And Long-Term Weight Maintenance

International Journal of Translation & Community Medicine, 2014
Objective: To determine if there are differences in short-term weight loss and long-term weight maintenance success by age or gender. Methods: Patients were enrolled in a Midwestern weight loss clinic. The primary outcome measures were short-term weight loss success (achieving ≥ 10% of the initial body weight loss (IBWL) at three months) and long-term ...
Dong F, Moore JB, Ablah E, Bobbie G. Paull-Forney, Collins T   +4 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Concept-based term weighting for web information retrieval

, 2006
In this paper we present a novel technique for determining term importance by exploiting concept based information found in ontologies. Calculating term importance is a significant and fundamental aspect of most information retrieval approaches and it is
Zakos, John., Brijesh Verma (9842312), Verma, Brijesh., J Zakos (9872915)   +3 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

CLUSTER-BASED TERM WEIGHTING AND DOCUMENT RANKING MODELS

, 2011
A term weighting scheme measures the importance of a term in a collection. A document ranking model uses these term weights to find the rank or score of a document in a collection.
Murugesan, Keerthiram
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source