Results 61 to 70 of about 4,280,482 (303)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Energy density and weight change in a long-term weight-loss trial [PDF]
Identifying dietary factors that contribute to weight loss is an important task given the health risks linked to obesity and the difficulty in achieving weight loss among obese individuals. This study examined the effect of lowered energy density on weight loss. Subjects were 213 men and women with BMI of 30–39 kg/m
Welsh Ericka M +9 more
openaire +3 more sources
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Imbalanced sentiment is one of the key classification issues. Many studies have proposed imbalanced sentiment classification improvements, but the topic remains problematic as a major challenge.
Khanista Namee, Jantima Polpinij
doaj
Supervised term weighting for automated text categorization [PDF]
The construction of a text classi.er usually involves (i) a phase of term selection, in which the most relevant terms for the classi.cation task are identi.ed, (ii) a phase of term weighting, in which document weights for the selected terms are computed, and (iii) a phase of classi.er learning, in which a classi.er is generated from the weighted ...
Debole F, Sebastiani F
openaire +7 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Bento and Buffet: Two Approaches to Flexible Summative Assessment
This practice-sharing piece outlines two main approaches to flexible summative assessment schemes, including for each approach one example from my practice and another from a published study. The bento approach offers the same assessments to all students
Nicky Didicher
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Retrieval of source documents in a text reuse system
The architecture of the text-reuse detection system consists of three main modules, i.e., source retrieval, text analysis, and knowledge-based postprocessing. Each module plays an important role in the accuracy rate of the detection outputs.
Nathaniel Clarence Haryanto +2 more
doaj +1 more source

